Results 61 to 70 of about 609 (248)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

ON OBSERVATIONAL PHENOMENA RELATED TO KERR SUPERSPINARS

Acta Polytechnica, 2014
We investigate possible signatures of a Kerr naked singularity (superspinar) in various observational phenomena. It has been shown that Kerr naked singularities (superspinars) have to be efficiently converted to a black hole due to accretion from ...
Zdenek Stuchlik, Jan Schee
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Angular Momentum Accretion onto Disc Galaxies [PDF]

Proceedings of the International Astronomical Union, 2018
AbstractThroughout the Hubble time, gas makes its way from the intergalactic medium into galaxies fuelling their star formation and promoting their growth. One of the key properties of the accreting gas is its angular momentum, which has profound implications for the evolution of, in particular, disc galaxies.
Fraternali, Filippo, Pezzulli, Gabriele
openaire   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Inferring the physics of protoplanetary disc evolution from the irradiated Cygnus OB2 region

Astronomy & Astrophysics
Context. Determining the physical processes driving protoplanetary disc evolution is of paramount importance for understanding planet formation. Our current understanding has crystallised around two possible evolution scenarios: turbulent viscosity and ...
Weder Jesse, Winter Andrew J., Mordasini Christoph   +2 more
doaj   +1 more source

BEYOND THE STANDARD MODEL OF THE DISC–LINE SPECTRAL PROFILES FROM BLACK HOLE ACCRETION DISCS

Acta Polytechnica, 2014
The strong gravitational field of a black hole has distinct effects on the observed profile of a spectral line from an accretion disc near a black hole.
Vjaceslav Sochora, Vladimír Karas, Jirí Svoboda, Michal Dovciak   +3 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Flavor instabilities in the neutrino line model

Physics Letters B, 2015
A dense neutrino medium can experience collective flavor oscillations through nonlinear neutrino–neutrino refraction. To make this multi-dimensional flavor transport problem more tractable, all existing studies have assumed certain symmetries (e.g., the ...
Huaiyu Duan, Shashank Shalgar
doaj   +1 more source