Results 111 to 120 of about 7,874 (265)

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

When Sustainability Reporting Becomes a Strategy: The Impact of Financial Performance and Institutional Pressures From EU Sustainability Reporting Regulations on ESG Decoupling

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT Mitigating environmental, social, and governance (ESG) decoupling is essential to advancing reliable sustainability disclosure and ensuring that ESG reporting fulfills its intended purpose. This study aims to provide critical insights into the organizational and contextual elements that could intensify or diminish ESG decoupling. Using a multi‐
Catarina Cepêda, Albertina Paula Monteiro, Cristina Aibar‐Guzmán   +2 more
wiley   +1 more source

From Nonfinancial Reporting to Management Control: A GRI‐Based Sustainability Balanced Scorecard

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The integration of sustainability into strategic management systems has shifted from a reporting‐oriented exercise to a challenge of implementation, control, and accountability. Although the SBSC is widely acknowledged as a suitable framework to embed environmental and social objectives into strategy execution, its practical application ...
Piedad Ortiz‐Fernández, Belén Payán‐Sánchez, Eva Carmona‐Moreno   +2 more
wiley   +1 more source

Corporate Social Responsibility and Corporate Tax Avoidance in Europe: Evidence From the Anti‐Tax Avoidance Directives

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT This study examines the relationship between corporate social responsibility (CSR) and corporate tax avoidance (CTA) in the European Union, exploiting institutional variation arising from CSR disclosure regimes and the introduction of the Anti‐Tax Avoidance Directives (ATAD).
Alessandro Migliavacca
wiley   +1 more source

Micronutrient Status in Children Suffering From Anorexia Nervosa: A Cohort of 349 Patients in a Referral Center for Eating Disorders

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a serious illness in which more than half of all deaths are due to malnutrition. Critically low energy and protein intake are known causes of massive weight loss, whereas micronutrient deficiencies due to a low‐calorie food pattern remain poorly characterized in children with AN. Micronutrient deficiencies in
Zenaida Iordan, Diane Morfin, Marion Bernetiere, Marie Fauchet, Noël Peretti, Bérénice Segrestin, Pierre Poinsot   +6 more
wiley   +1 more source

Consistent financial practices at community sites improve performance and sustainability: A case study of validated practices at a community clinical research site. [PDF]

J Clin Transl Sci
Hightower B, Fox D.
europepmc   +1 more source

PondNet – towards a global network of experiments on the effects of climate change on aquatic ecosystems

Ecography, EarlyView.
Global change is reshaping the distribution of biodiversity and the functioning of ecosystems. Predicting the long‐term consequences of such changes remains a challenge due to a need for a clear understanding of the mechanisms underpinning ecosystem‐level responses, as well as the role of geographical and environmental contingencies.
Miguel G. Matias, Dominique Gravel, Jonathan M. Chase, Carla Pinto‐ Cruz, David García‐ Callejas, M. Thomas P. Gilbert, Mathew A. Leibold, Dora Neto, Cátia L. Pereira, Carlos Ramos, Pedro M. Raposeiro, Alejandro Rozenfeld, Katarzyna Sroczynska, David R. Vieites, Guy Woodward, Miguel B. Araújo   +15 more
wiley   +1 more source

Headwinds in Breast Cancer Research: The Case for Pragmatic Radiotherapy De-escalation Studies. [PDF]

J Clin Oncol
Braunstein LZ, Mitchell MP, Khan AJ, Sikov WM, Mamounas EP, Julian TB, Wolmark N.   +6 more
europepmc   +1 more source

Geographic biases and gaps in the sampling of plant–pollinator networks

Ecography, EarlyView.
Plant–pollinator interactions are essential for maintaining biodiversity and supporting food production, yet inferences drawn from network syntheses may be shaped by where interaction data are generated and which datasets are most reused. Here, we quantify the global distribution of published plant–pollinator networks, assess how publication rates vary
Emanuelle L. S. Brito, Rose McDonald, Mário Almeida‐Neto, Lauren C. Ponisio   +3 more
wiley   +1 more source