Results 201 to 210 of about 909,370 (300)

A Randomized Trial Evaluating Personalized Versus Guideline-Based Well Follow-Up Strategies for Patients with Early Breast Cancer: Feasibility Outcomes. [PDF]

Curr Oncol
Beltran-Bless AA, Himmelman E, Kim A, Pond GR, Fallah P, Ng T, Hilton J, Savard MF, Larocque G, Baines KA, Primeau K, Saunders D, Allard D, Vandermeer L, Clemons M.   +14 more
europepmc   +1 more source

Prolonged fenfluramine use in open‐label studies of Dravet or Lennox–Gastaut syndromes: Long‐term safety, tolerability, patient global functioning, and considerations for interpreting effectiveness

Epilepsia, EarlyView.
This graphical abstract provides an overview of the content from this open‐label extension study of fenfluramine use in patients with Dravet syndrome or Lennox‐Gastaut syndrome. Abstract Objective Long‐term safety and global functioning are reported in patients with Dravet syndrome (DS) or Lennox–Gastaut syndrome (LGS) treated with fenfluramine in an ...
Antonio Gil‐Nagel, Kelly G. Knupp, Boudewijn Gunning, Domenica Immacolata Battaglia, Elizabeth A. Thiele, Ingrid E. Scheffer, An‐Sofie Schoonjans, Rima Nabbout, Nathalie Villeneuve, Kerstin Alexandra Klotz, Nicola Specchio, Rocio Sanchez‐Carpintero, Marta Zolnowska, Anne‐Liv Schulz, Lily Perrin, Najla Dickson, Mélanie Langlois, Amélie Lothe, Joseph Sullivan   +18 more
wiley   +1 more source

Group sequential clinical trial designs for composite endpoints incorporating recurrent and terminal events. [PDF]

Biometrics
Lian Q, Ahn KW, Kim S, Logan BR, Solh M, Martens MJ.   +5 more
europepmc   +1 more source

Perils and progress in epilepsy surgery utilization: Twenty‐five years later

Epilepsia, EarlyView.
Abstract More than 25 years have passed since the first randomized controlled trial (RCT) established that surgery is superior to continued anti‐seizure medication (ASM) for drug‐resistant temporal lobe epilepsy, and nearly as long since a joint practice parameter urged that appropriate surgical candidates be referred to a specialized center for ...
Dario J. Englot
wiley   +1 more source

Beyond numbers: The governance role of data assets in real earnings management. [PDF]

PLoS One
Zhang M, Qian H, Ma T.
europepmc   +1 more source

Phenotypic and transcriptomic characterization of biallelic RNU2‐2 developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective A significant proportion of individuals with suspected genetic developmental and epileptic encephalopathies (DEEs) remain unsolved following whole genome sequencing (WGS). Here we describe biallelic RNU2‐2 variants causing a recently reported, severe, recessive DEE.
Olivia J. Henry, Nadja Pekkola Pacheco, Irene Duba, Magnus Burstedt, Daniel Carlberg, Angelica M. Delgado‐Vega, Anna Hammarsjö, Sofie Ivarsson, Tord Jonson, Kristina Karrman, Nicole Lesko, Åsa Lindfors, Daniel Nilsson, Mia Olsson Engman, Lucía Peña‐Pérez, Erik Stenund, Fulya Taylan, Malin Ueberschär, Samuel Wiafe, Sofia Ygberg, Anna Lindstrand, Anna Wedell, Ann Nordgren, Tommy Stödberg   +23 more
wiley   +1 more source

Rationale and design of the SENTRY trial: sentinel node and organ-preserving surgery versus segmental resection in stage I colon cancer. [PDF]

BJS Open
van de Laar BCT, Sikkenk DJ, Tanis PJ, Verheijen PM, Schwartz MP, Akol H, Arensman R, Voskens FJ, Moons LMG, de Vos Tot Nederveen Cappel WH, van Westreenen HL, Nagengast WB, Consten ECJ.   +12 more
europepmc   +1 more source

Cumulative electroconvulsive therapy sessions and focal epilepsy: A nationwide cohort study in Japan

Epilepsia Open, EarlyView.
Abstract Objective Electroconvulsive therapy (ECT) is widely used for severe psychiatric disorders, yet concerns remain regarding possible epileptogenic effects associated with prolonged or repeated exposure. We examined the association between cumulative ECT sessions and focal epilepsy in a nationwide Japanese cohort.
Masahiro Hata, Yuki Miyazaki, Hisaki Omori, Shun Takahashi, Manabu Ikeda   +4 more
wiley   +1 more source

Prognostic factors in paediatric-onset multiple sclerosis: a narrative review. [PDF]

J Neurol
Achille M, Copetti M, Guerra T, Ferri C, Iaffaldano P, D'Alfonso S, Pugliatti M, Palumbi R, Simone M.   +8 more
europepmc   +1 more source

Changes in effectiveness and safety in patients with Lennox–Gastaut syndrome transitioning from the fenfluramine randomized controlled trial to open‐label extension study

Epilepsia Open, EarlyView.
This graphical abstract provides an overview of the content from this post hoc analysis describing the trajectories of fenfluramine effectiveness and safety, along with dose changes over time, in patients with Lennox‐Gastaut syndrome. Abstract In the phase 3 randomized controlled trial (RCT; NCT03355209) of fenfluramine in Lennox–Gastaut syndrome (LGS),
Rima Nabbout, Orrin Devinsky, Lieven Lagae, Ingrid E. Scheffer, Renzo Guerrini, Joseph Sullivan, Antonio Gil‐Nagel, Sameer M. Zuberi, Kate Riney, Patrick Healy, Jayne Abraham, Rebecca Zhang Roper, Mélanie Langlois, Amélie Lothe, Kelly G. Knupp   +14 more
wiley   +1 more source