Results 101 to 110 of about 29,072 (293)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Intermediate Biblical Greek Reader: Galatians and Related Texts

open access: yes, 2018
After completing basic biblical Greek, students are often eager to continue to learn and strengthen their skills of translation and interpretation. This intermediate graded reader is designed to meet those needs. The reader is “intermediate” in the sense
Gupta, Nijay K., Sandford, Jonah M.
core  

Alternating predicates in Icelandic and German: a sign-based construction grammar account [PDF]

open access: yes, 2014
A long-standing divide between Icelandic and German in the literature takes for granted that there are non-nominative subjects in Icelandic, while corresponding arguments in German have been analyzed as objects (Zaenen, Maling & Thráinsson 1985 ...
Barddal, Johanna   +2 more
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Arabic parsing using grammar transforms [PDF]

open access: yes, 2010
We investigate Arabic Context Free Grammar parsing with dependency annotation comparing lexicalised and unlexicalised parsers. We study how morphosyntactic as well as function tag information percolation in the form of grammar transforms (Johnson, 1998 ...
Tounsi, Lamia, van Genabith, Josef
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

open access: yesFEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj   +3 more
wiley   +1 more source

Null objects and accusative clitics in Romanian

open access: yesBucharest Working Papers in Linguistics, 2009
Starting from the identification of the obligatory contexts in which the Accusative clitic occurs in Romanian we offer a unifying analysis of its role across all the identified contexts.
Martine Coene, Larisa Avram
doaj  

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