Results 191 to 200 of about 97,072 (276)

Strategies for Target Identification and Mechanism Elucidation in Phytochemicals

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Strategies for Target Identification of Phytochemicals: Labeling Methods VS. Non‐Labeling Methods ABSTRACT Drug targets serve as the fundamental biological basis through which phytochemicals exert their therapeutic effects, and target discovery represents both the core challenge and the rate‐limiting step in elucidating the mechanisms of action of ...
Jialing Chen, Yan Linghu, Dasong Wang, Weidong Pan, Kegang Linghu   +4 more
wiley   +1 more source

Association of the ACE2 rs879922 Polymorphism with Glaucoma Risk and Serum ACE2 Levels. [PDF]

J Clin Med
Cieślińska A, Krzykowska N, Rozmus D, Fiedorowicz E, Kuklo P, Płomiński J, Grzybowski A.   +6 more
europepmc   +1 more source

AVIDbase: A biologically accurate structural dataset of nanobody‐antigen complexes

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Accurate structural data in a standardized format is one of the key factors behind the success of machine learning (ML)‐based methods for protein design and structure prediction. However, their application to nanobody‐antigen complexes has lower success rates compared to globular protein complexes, partly due to the limited amount of high ...
Tadej Medved, Jurij Lah, Goran Miličić, San Hadži   +3 more
wiley   +1 more source

Extracellular Vesicles as Molecular Regulators of Viral Infection: Implications for COVID-19 and Future Viral Pandemics. [PDF]

Curr Issues Mol Biol
Dutta S, Dutta S, Han Y, Zhu Y, Almuntashiri S, Somanath PR, Narayanan SP, Islam S, Wang X, Zhang D.   +9 more
europepmc   +1 more source

ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2. [PDF]

Mol Biomed
Wang Y, Xu J, Chen Y, Xiao X, Zhu Y, Yu L, Shi W, Li J, Li J, Zhu C.   +9 more
europepmc   +1 more source

The Equilibrium Response of Atmospheric Machine‐Learning Models to Uniform Sea Surface Temperature Warming

Journal of Advances in Modeling Earth Systems, Volume 18, Issue 9, September 2026.
Abstract Machine learning (ML) models for the global atmosphere that are capable of producing stable, multi‐year simulations of Earth's climate have recently been developed. However, the ability of these ML models to generalize beyond the training distribution remains an open question. In this study, we evaluate the climate response of several state‐of‐
Bosong Zhang, Timothy M. Merlis
wiley   +1 more source

Investigating the Short‐Term Changes of the Electrocardiogram Indicators During Hospitalization in Patients With COVID‐19 Following the Use of Tocilizumab

Annals of Noninvasive Electrocardiology, Volume 31, Issue 5, September 2026.
Tocilizumab, an IL‐6 inhibitor used in severe COVID‐19, may have cardiovascular effects. This study examined short‐term electrocardiographic (ECG) changes 24 h before versus 24 h after tocilizumab injection in PCR‐positive COVID‐19 patients. Retrospective study of 33 ICU‐admitted COVID‐19 patients (36.4% male, age 37–79 years). ECG parameters including
Mahdi Zahedi, Golnaz Houshmand, Tabassom Hosseini   +2 more
wiley   +1 more source

Cadherin 1 negatively regulates SARS-CoV-2 infection in the olfactory epithelium. [PDF]

EMBO Rep
Li W, Shi Y, Li X, Liu M, Liu J, Qin Z, Lin H, Wang Y, Yu Y.   +8 more
europepmc   +1 more source

Transposon Vectors Enable Accelerated Development of Cellular Assay Platforms for the Identification and Characterization of Anti-Viral Small-Molecule Cell-Entry Inhibitors and Neutralizing Antibodies. [PDF]

Biomedicines
Pißarreck M, Katsoutas K, Kinder CL, Stitz J.   +3 more
europepmc   +1 more source

Association of ACE2 gene polymorphisms with risk of pulmonary arterial hypertension in neonates with congenital heart disease. [PDF]

BMC Cardiovasc Disord
Chen Y, Wang C, Lin Q, Chen J, Lin L, Luo S, Li Y, Deng L.   +7 more
europepmc   +1 more source