Results 141 to 150 of about 69,918 (298)

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Effect of Mineralocorticoid Receptor Antagonism and ACE Inhibition on Angiotensin Profiles in Diabetic Kidney Disease: An Exploratory Study. [PDF]

Diabetes Ther, 2021
Kovarik JJ, Kaltenecker CC, Domenig O, Antlanger M, Poglitsch M, Kopecky C, Säemann MD.   +6 more
europepmc   +1 more source

Addition of AT1 blocker fails to overcome resistance to ACE inhibition in adriamycin nephrosis

, 2002
Addition of AT1 blocker fails to overcome resistance to ACE inhibition in adriamycin nephrosis.BackgroundAngiotensin-converting enzyme (ACE) inhibitors provide renoprotection, but there is considerable interindividual variability in therapeutic efficacy,
Tiebosch, Anton T.M.G., Bos, Hendrik, De Jong, Paul E., De Zeeuw, Dick, Henning, Robert H., De Boer, Eric, Navis, Gerjan   +6 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Inhibition of angiotensin converting enzyme (ACE) in plasma and tissue

, 1990
Inhibition of angiotensin-converting enzyme (ACE) in rat plasma and tissue was studied after administration of quinapril, a new orally active ACE inhibitor with an intermediate duration of action.
JOHNSTON CI, CHEN BZ, FABRIS, BRUNO, PUPIC V, PERICH R   +4 more
core  

Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition

, 2003
SummaryAn increased risk of thrombembolic events in congestive heart failure (CHF) has been attributed to a hypercoagulable state including vascular endothelial dysfunction and platelet activation.After experimental myocardial infarction, male Wistar ...
Martin Eigenthaler, Anna Kobsar, Steven Hildemann, Andreas Schäfer, Daniela Fraccarollo, Michael Christ, Johann Bauersachs, Ulrich Walter   +7 more
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

ACE Inhibition Modulates Myeloid Hematopoiesis after Acute Myocardial Infarction and Reduces Cardiac and Vascular Inflammation in Ischemic Heart Failure. [PDF]

Antioxidants (Basel), 2021
Rudi WS, Molitor M, Garlapati V, Finger S, Wild J, Münzel T, Karbach SH, Wenzel P.   +7 more
europepmc   +1 more source

Recent insight into therapy of congestive heart failure: focus on ACE inhibition and angiotensin-II antagonism

, 1999
One possible intervention to interrupt the deleterious effects of the renin-angiotensin system is suppression of angiotensin II (Ang II) formation by inhibition of angiotensin-converting enzyme (ACE).
Esler, Murray D., Brunner-La Rocca, Hans Peter, Hans Peter Brunner-La Rocca, Gautam Vaddadi, Vaddadi, Gautam, Murray D. Esler   +5 more
core   +1 more source