Results 131 to 140 of about 89,590 (297)

SS-induced decrease in ACE and phosphorylation on Ser1270 is counteracted by ACE inhibitor treatment.

open access: yes, 2013
(A) ACE phosphorylation on Ser1270, (B) ACE protein expression downregulation, and (C) Representative western blots. Saphenous vein endothelial cells were concomitant submitted to laminar shear stress (15 dyne/cm2; SS 18 h) and treated with ACE inhibitor
Ayumi Aurea Miyakawa (345502)   +3 more
core   +1 more source

Therapeutic effects of fosinopril - ACE inhibitor

open access: yesКардиоСоматика, 2015
The review article dials with the characteristics of fosinopriltherapeutic features, apparently associated with the fact that it contains phosphorus. It has special specter possessing the numerous of organotropic effects and good tolerability and safety,
D. M Aronov
doaj  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Aloe polysaccharide promotes keratinocyte proliferation, migration, and differentiation by upregulating the EGFR/PKC-dependent signaling pathways

open access: yesScientific Reports
Aloe vera is a popular medicinal plant in the cosmetic, pharmaceutical, and food industries. Acemannan (ACE), a β-(1,4)-acetylated mannan, is one of the bioactive compounds isolated from the A. vera gel.
Ching-Yuan Cheng   +6 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

GAMBARAN PERESEPAN ACE INHIBITOR PADA PASIEN GAGAL JANTUNG YANG DIRAWAT INAP DI RSUP DR KARIADI SEMARANG PERIODE JANUARI-DESEMBER 2013 [PDF]

open access: yes, 2014
Latarbelakang Gagal jantung adalahs indroma klinis yang disebabkan oleh kelainan struktur atau fungsi jantung. Prevalensi gagal jantung semakin meningkat dan menimbulkan penurunan kualitas hidup.
Arianda, R. Hasya   +2 more
core  

Unraveling the Pivotal Role of Bradykinin in ACE Inhibitor Activity

open access: yes, 2016
Historically, the first described effect of an angiotensin converting enzyme (ACE) inhibitor was an increased activity of bradykinin, one of the substrates of ACE.
Bortolotto, L., TADDEI, STEFANO
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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