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Abstract ACE inhibitors were first introduced because of their vasodilatory properties. It is now understood that the beneficial effects arise from the antagonism of the renin–angiotensin–aldosterone system. ACE inhibitors are first-line agents for all patients with HFrEF—this is also true in patients with asymptomatic LVSD.
Roy S. Gardner +3 more
openaire +1 more source
Roy S. Gardner +3 more
openaire +1 more source
Trends in kinase drug discovery: targets, indications and inhibitor design
Nature Reviews Drug Discovery, 2021Misty M Attwood, Stefan Knapp
exaly