Molecular Oncology, EarlyView.This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga +8 more
wiley +1 more source
E097 Mibefradil, a selective T-type CA2 channel blocker, compares favorably with the ace inhibitor enalapril in the treatment of hypertension [PDF]
, 1998 Gianmarco Villa
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Evaluating the Role of the Renin-angiotensin System in COVID-19: Implications for ACE Inhibitor and ARB Use During SARS-CoV-2 Infection. [PDF]
J Cell ImmunolTritsch SR +13 more
europepmc +1 more source
Corrigendum to: ACE inhibitor-induced small bowel angioedema, mimicking an acute abdomen. [PDF]
J Surg Case Rep, 2020 Parreira R +5 more
europepmc +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Comparable long-term renoprotection of amlodipine to ACE inhibitors in patients with moderate to severe renal dysfunction. [PDF]
, 1999 Hitoshi Kumagai
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Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey [PDF]
, 2017 Bateman, Randy J, et al,
core +2 more sources
E105 Realization of anti-angina and anti-ischemic ACE-inhibitor cilazapril effects in hypertensive patients with coronary artery disease [PDF]
, 1998 E. N. Pavlyukova
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