Results 171 to 180 of about 163,866 (279)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Class-Specific Effects of ARBs Versus ACE Inhibitors on Survival and Cardiovascular Outcomes in MASLD. [PDF]

Int J Mol Sci
Ryu T, Seo YJ, Lee J, Han JW, Yang H, Yang K.   +5 more
europepmc   +1 more source

ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells. [PDF]

Reprod Biol, 2022
Fernando SR, Chen X, Cheng KW, Wong BP, Qi S, Jiang L, Kodithuwakku SP, Ng EH, Yeung WS, Lee KF.   +9 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Angiotensin-Converting Enzyme (ACE) Inhibitors and Statins Mitigate Negative Cardiovascular and Pulmonary Effects of Particulate Matter in a Mouse Exposure Model. [PDF]

Antioxidants (Basel)
Junglas T, Daiber A, Kuntic I, Valar A, Zheng J, Oelze M, Strohm L, Ubbens H, Hahad O, Bayo Jimenez MT, Münzel T, Kuntic M.   +11 more
europepmc   +1 more source

The Combination of Beta-Blockers and ACE Inhibitors Across the Spectrum of Cardiovascular Diseases. [PDF]

Cardiovasc Drugs Ther, 2023
Strauss MH, Hall AS, Narkiewicz K, Narkiewicz K.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Antihypertensive therapy to prevent cardiac death: A study of combined ACE inhibitors and β-blockers-a retrospective cohort study in Tsunan Town, Japan. [PDF]

PLoS One
Ishikawa S, Hayashi Y, Abe T, Tanaka S.
europepmc   +1 more source

Hospitalisations Related to the Combination of ACE Inhibitors and/or Angiotensin Receptor Blockers with Diuretics and NSAIDs: A Post Hoc Analysis on the Risks Associated with Triple Whammy. [PDF]

Healthcare (Basel), 2023
Mattioli I, Bettiol A, Crescioli G, Bonaiuti R, Mannaioni G, Vannacci A, Lombardi N, MEREAFaPS Study Group.   +7 more
europepmc   +1 more source

Angiotensin II receptor antagonists for the treatment of heart failure: what is their place after ELITE-II and Val-HeFT? [PDF]

, 2001
McMurray, John J.V.
core   +1 more source