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Pediatric Clinics of North America, 2000
Although whole-cell pertussis vaccines have been highly effective in preventing whooping cough, their common and burdensome adverse reactions have spurred the development of safer alternatives. Seven acellular vaccines are licensed in one or more countries; four have been licensed thus far in the United States, and more may follow.
M D, Decker, K M, Edwards
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Although whole-cell pertussis vaccines have been highly effective in preventing whooping cough, their common and burdensome adverse reactions have spurred the development of safer alternatives. Seven acellular vaccines are licensed in one or more countries; four have been licensed thus far in the United States, and more may follow.
M D, Decker, K M, Edwards
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Acellular Pertussis Vaccine Booster
Pediatrics, 1993The editors of Pediatrics have asked us to comment on the study by Pichichero et al,1 because our report of booster vaccination with this vaccine, published in Pediatrics in 1989,2 raised some questions with regard to the safety of the vaccine. The present study, with a design similar to ours, showed different and far more encouraging results: no ...
M, Blennow, M, Granstrom
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ACELLULAR PERTUSSIS VACCINES IN ADULTS
Infectious Disease Clinics of North America, 1999The pathogenesis of pertussis, and the epidemiology and clinical manifestations of pertussis after childhood are reviewed as a background for a discussion of recent clinical trials of acellular pertussis vaccines in adults, and the vaccines' potential for routine use in adolescents and adults.
W A, Keitel, K M, Edwards
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Acellular pertussis vaccines in China
Vaccine, 2012In China, whole-cell pertussis (Pw) vaccines were produced in the early 1960s and acellular pertussis (Pa) vaccines were introduced in 1995. Pa vaccines have now almost completely replaced Pw vaccines in the national immunization program. To strengthen the regulation of vaccines used in China, a vaccine lot release system was established in 2001 and Pa
Lichan, Wang +2 more
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Development of Acellular Pertussis Vaccines
Biologicals, 1999In 1974, the authors reported the isolation and characterization of protective antigens of Bordetella pertussis in mice. With this information, an acellular pertussis vaccine was developed, composed mainly of pertussis toxin (PT) and filamentous haemagglutinin (FHA).
Y, Sato, H, Sato
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Acellular Pertussis Vaccines for Infants
New England Journal of Medicine, 1996Whole-cell vaccines, which are suspensions of killed Bordetella pertussis organisms, are among our most effective and least satisfactory vaccines.
K M, Edwards, M D, Decker
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Acellular Pertussis Vaccines for Adolescents
The Pediatric Infectious Disease Journal, 2005The epidemiology of pertussis is changing, with a clear increase in the number of cases diagnosed in adolescents and adults. This development has spurred studies and anticipated licensure of safer diphtheria, tetanus, acellular pertussis combined (Tdap) vaccines for this older population.Literature review.Tdap vaccines are safe and immunogenic when ...
Michael E, Pichichero, Janet R, Casey
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Pertussis vaccine controversies and acellular pertussis vaccine
The Indian Journal of Pediatrics, 2003Pertussis still continues to cause significant morbidity and mortality worldwide. Because of the high reactogenicity of whole cell pertussis vaccine, it had evoked public controversy in several countries. In 1970 Japan abandoned use of whole cell pertussis vaccine and mounted efforts to develop better vaccine.
Raju C, Shah, Anuj R, Shah
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Combination vaccines consisting of acellular pertussis vaccines
The Pediatric Infectious Disease Journal, 1997Combination vaccines consisting of multiple vaccine antigens delivered in a single injection simplify vaccine administration. Combining multiple antigens into one injection, however, presupposes that the administration of multiple vaccines in combination will not reduce the safety and immunogenicity of the component vaccines.
K M, Edwards, M D, Decker
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Standardization of Acellular Pertussis Vaccines
Biologicals, 1999In comparison with the current whole cell pertussis vaccine, the new generation of acellular pertussis vaccines opens new opportunities to improve the standardization of the product, because well defined and characterized components are used in these new products.However, different compositions, purification and inactivation methods are used by ...
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