Results 41 to 50 of about 778 (161)
Advanced Science, EarlyView.Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang +12 more
wiley +1 more source
És ben sabut que la Ciència i Tecnologia dels Biomaterials és una disciplina de creació molt recent. Fins al punt que encara no existeix una normativa sòlida relativa a l'avaluació de la biocomptabilitat dels biomaterials. El treball que presentem pretén
Gil, F. J. +2 more
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Material docent: disseny, simulació i assaig d’un suport per cistella de bicicleta i d’un esglaó d’escala de cargol [PDF]
, 2011 Aquest Projecte Final de Carrera pretén modelar, simular i assajar de manera experimental un suport per a cistella de bicicleta i un esglaó d’escala de cargol per tal de comparar els valors de deformació i de tensions obtinguts amb la simulació ...
Sánchez González, Alberto +1 more
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Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer
Advanced Science, EarlyView.Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen +13 more
wiley +1 more source
Rehabilitació, adecuació energètica i canvi d'ús d'edifici plurifamiliar en testera [PDF]
, 2010 El present document, representa la part escrita o memòria descriptiva i constructiva del meu Projecte Fi de Grau. La segona part, esta representada per un conjunt de plànols on es grafíen les solucions constructives que s’han adoptat, a totes les ...
Robles Olmo, Noelia
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Bioinspired Adaptive Leg‐Claw Enables Robust Perching and Grasping for UAVs
Advanced Science, EarlyView.Inspired by owl limb morphology and bat roosting behavior, this study presents a bioinspired adaptive leg‐claw mechanism that enables UAVs to perform robust and versatile perching and grasping. The design integrates a four‐link tibial structure, tension‐driven deformable feet, and active control, enabling stable perching on various branches and ...
Tianyu Cheng +6 more
wiley +1 more source
Noves tendències i propietats dels materials de muntures [PDF]
, 2017 Aquest treball de final de grau, estructurat en una part teòrica i una experimental, tracta sobre els materials més innovadors utilitzats en la fabricació de muntures.
Pizarro Aragones, Helena
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Advanced Science, EarlyView.Multi‐omics analyses uncover breed‐specific cis‐regulatory landscapes and higher‐order chromatin architectural differences that underlie early postnatal muscle fiber divergence in pigs. A super‐enhancer upstream of PPP3CB recruits MEF2C to activate PPP3CB transcription, while the PPP3CB–MEF2C positive feedback loop promotes oxidative muscle fiber ...
Shuailong Zheng +8 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley +1 more source
Advanced Science, EarlyView.OsGSK2‐OsTCP19 module regulating nitrate response and lateral root (LR) development. Low‐nitrate condition results in reduced BR response, accumulation of OsGSK2 and phosphorylated OsTCP19, which suppresses the expression of nitrate‐responsive genes and LR‐development genes and impairs rice growth.
Yongqiang Liu +11 more
wiley +1 more source