Results 221 to 230 of about 69,799 (276)
Some of the next articles are maybe not open access.
Engineered acetaldehyde dehydrogenase for the efficient degradation of acetaldehyde
Journal of Environmental Management, 2023Acetaldehyde is highly cytotoxic and widely presents in food and the environment. Aldehyde dehydrogenase (ALDH) can degrade acetaldehyde to non-toxic acetic acid, showing potential for acetaldehyde elimination. However, a lack of high-throughput methods for screening efficient variants is a significant obstacle to ALDH design.
Zheng Peng +3 more
openaire +2 more sources
BRCA1 And BRCA2 Tumor Suppressors Protect Against Endogenous Acetaldehyde Toxicity
EMBO Molecular Medicine, 2017 Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, particularly ...
Nelson Tang +2 more
exaly +2 more sources
Hepatotoxicity of Acetaldehyde
1980All known pathways of ethanol oxidation in the liver result in production of acetaldehyde. Until recently, however, the fate of this metabolite of ethanol has been rather neglected because of methodological difficulties in its measurement. However, recent technological advancements have permitted the development of acceptable methods to detect ...
C S, Lieber +5 more
openaire +2 more sources
Metabolic effects of acetaldehyde
Biochemical Society Transactions, 1988Acetaldehyde, the toxic product of ethanol metabolism in the liver, covalently binds to a variety of proteins, thereby altering liver function and structure. Through its binding to tubulin, acetaldehyde decreases the polymerization of microtubules thereby impairing protein secretion and favouring their retention, with associated swelling of hepatocytes.
openaire +2 more sources