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Engineered acetaldehyde dehydrogenase for the efficient degradation of acetaldehyde

Journal of Environmental Management, 2023
Acetaldehyde is highly cytotoxic and widely presents in food and the environment. Aldehyde dehydrogenase (ALDH) can degrade acetaldehyde to non-toxic acetic acid, showing potential for acetaldehyde elimination. However, a lack of high-throughput methods for screening efficient variants is a significant obstacle to ALDH design.
Zheng Peng   +3 more
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Pharmacology of acetaldehyde

Canadian Journal of Physiology and Pharmacology, 1983
The pharmacological effects of acetaldehyde on the cardiovascular system, the liver, monoamine neurotransmitter metabolism, brain function and behaviour, and voluntary ethanol drinking are reviewed. The pharmacological effects of acetaldehyde, produced during the interaction of ethanol with the aldehyde dehydrogenase inhibitors disulfiram, calcium ...
J F, Brien, C W, Loomis
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Hepatotoxicity of Acetaldehyde

1980
All known pathways of ethanol oxidation in the liver result in production of acetaldehyde. Until recently, however, the fate of this metabolite of ethanol has been rather neglected because of methodological difficulties in its measurement. However, recent technological advancements have permitted the development of acceptable methods to detect ...
C S, Lieber   +5 more
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Hepatotoxicity of acetaldehyde in rats

Toxicology Letters, 1987
The ability of acetaldehyde to initiate hepatotoxicity as evidenced by enzyme leakage, hepatic fat accumulation and histological alterations was studied in rats. Neither oral nor intraperitoneal treatment with acetaldehyde had any hepatotoxic effect, even following aldehyde dehydrogenase inhibition by disulfiram.
O, Strubelt   +4 more
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Tautomerism and proton transfer in photoionized acetaldehyde and acetaldehyde–water clusters

Journal of Mass Spectrometry, 2014
Understanding the gas‐phase chemistry of acetaldehyde can be challenging because the molecule can assume several tautomeric forms, namely keto, enol and carbene. The two last forms are the most stable ionic forms. Here, insight into the gas‐phase cluster ion chemistry of homogeneous acetaldehyde and mixed water–acetaldehyde clusters is provided by mass
Di Palma TM, Bende A
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