Results 251 to 260 of about 136,607 (334)

A Thermodynamic Scale of Multiple Bonds Reducibility Based on G4 Calculations

open access: yesChemPhysChem, Volume 26, Issue 13, July 2, 2025.
An original scale for the reducibility of multiple bonds is established through G4 theoretical calculations in two steps: 1) comparing the gas heats of formation (ΔfH°) derived from G4 theoretical calculations with experimental values from NIST and ATcT, and 2) using the calculated ΔfH° (G4) to determine the hydrogenation enthalpies (ΔH2H ...
José Elguero, Ibon Alkorta
wiley   +1 more source

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

open access: yesAdvanced Science, Volume 12, Issue 25, July 3, 2025.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang   +11 more
wiley   +1 more source

Role of Pharmacology in Dentistry: A Review of Analgesics, Antibiotics, and Local Anesthetics. [PDF]

open access: yesCureus
Datta A   +6 more
europepmc   +1 more source

Paracetamol (acetaminophen) poisoning

open access: green, 1998
Philip A. Routledge   +9 more
openalex   +2 more sources

Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2070-2079, July 2025.
Abstract Aims Paltusotine is a novel, nonpeptide, selective somatostatin receptor 2 agonist in development for the treatment of acromegaly and carcinoid syndrome. This study investigated the mass balance, routes of excretion, absolute bioavailability and metabolite profile of orally administered paltusotine.
Rosa Luo   +6 more
wiley   +1 more source

Paracetamol and its metabolites in children and adults with spinal muscular atrophy – a population pharmacokinetic model

open access: yesBritish Journal of Clinical Pharmacology, Volume 91, Issue 7, Page 2045-2056, July 2025.
Abstract Aims The aim of the study was to investigate whether differences in paracetamol pharmacokinetics (PK) between spinal muscular atrophy (SMA) patients and healthy controls (HC) could be attributed to specific clinical covariates. Methods Nonlinear mixed‐effects modelling (NONMEM 7.4) was used to develop a population PK model, explore covariates ...
Qiaolin Zhao   +14 more
wiley   +1 more source

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