Results 91 to 100 of about 31,826 (289)

Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis

Angewandte Chemie, Volume 137, Issue 33, August 11, 2025.
This review provides a comprehensive account of the use of backbone N‐protecting groups in peptide synthesis. It includes detailed synthetic methods relating to their introduction and removal and their application to “difficult” peptides and proteins of biological significance in both academic and industry contexts.
Samuel J. Paravizzini, Linda M. Haugaard‐Kedström, Craig A. Hutton, John A. Karas   +3 more
wiley   +2 more sources

Impact of Mechanistic Modeling and Simulation Methodologies on Product‐Specific Guidance Development for Non‐Orally Administered Drug Products

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The U.S. Food and Drug Administration (FDA) publishes product‐specific guidances (PSGs), with bioequivalence (BE) recommendations for prospective generics. Developing BE recommendations for non‐orally administered drug products including long‐acting injectables (LAI), orally inhaled drug products, and drugs applied locally to the skin ...
Steven G. Chopski, Ross L. Walenga, Ming‐Liang Tan, Khondoker Alam, Andrew Babiskin, Lanyan Fang, Eleftheria Tsakalozou   +6 more
wiley   +1 more source

Evaluation of the treatment effectiveness of oral and intralesional steroids in idiopathic granulomatous mastitis using superb microvascular imaging

ANZ Journal of Surgery, EarlyView.
Abstract Objectives The objective of this study was to compare the efficacy of oral and intralesional steroid injection in the treatment of idiopathic granulomatous mastitis (IGM) cases with clinical, ultrasonography (US) and Superb microvascular imaging (SMI) findings.
Oğuz Karakayalı, Yasemin Kayadibi, Berrin Papila, Seda Aladag Kurt, Gökçen Yıldız Civan, Mehmet Velidedeoglu, Mehmet Halit Yılmaz   +6 more
wiley   +1 more source

Fluocinolone Acetonide 0.19 mg Implant in Patients with Cystoid Macular Edema Due To Irvine–Gass Syndrome

International Medical Case Reports Journal, 2021
João Heitor Marques,1 Ana Carolina Abreu,1 Nisa Silva,1 Angelina Meireles,1,2 Bernardete Pessoa,1,2 João Melo Beirão1,2 1Serviço de Oftalmologia, Centro Hospitalar e Universitário do Porto, Porto, Portugal; 2Instituto ...
Marques JH, Abreu AC, Silva N, Meireles A, Pessoa B, Melo Beirão J   +5 more
doaj  

Acute severe lameness associated with proliferative bone on the dorsal middle phalanx (19 cases)

Equine Veterinary Education, EarlyView.
Summary Background Injury resulting in proliferative new bone formation on the dorsal aspect of the middle phalanx (P2) has been recognised by equine veterinarians and is generally referred to as capsulitis. However, no retrospective case series has been published on the condition. Objectives To describe the clinical features, treatment, and outcome of
J. G. Fowlie, H. D. O'Neill, F. A. Nickels, S. Mattson   +3 more
wiley   +1 more source

A PAMPA Assay as Fast Predictive Model of Passive Human Skin Permeability of New Synthesized Corticosteroid C-21 Esters

Molecules, 2012
The permeation properties of twenty newly synthesized α-alkoxyalkanoyl and α-aryloxyalkanoyl C-21 esters of standard corticosteroids: Fluocinolone acetonide, dexamethasone, triamcinolone acetonide and hydrocortisone were established using a PAMPA assay ...
Katarina D. Karljikovic-Rajic, Sote M. Vladimirov, Jadranka V. Odovic, Olivera A. Cudina, Bojan D. Markovic   +4 more
doaj   +1 more source

Medial femorotibial and femoropatellar articular cartilage delamination following intra‐articular therapy with triamcinolone and gentamicin in five yearlings

Equine Veterinary Education, EarlyView.
Summary Subchondral lucencies (SCLs) of the medial femoral condyle (MFC) are a cause of lameness in young horses, potentially affecting future athletic performance. Due to the widespread use of pre‐sales screening radiographs for Thoroughbred weanlings and yearlings, these lesions are frequently identified at various stages of progression without the ...
C. P. Beggan, G. C. Quinn, C. W. McIlwraith   +2 more
wiley   +1 more source

Bone oedema‐like lesions at the enthesis of DIPJ collateral ligaments: MRI findings, management and outcome

Equine Veterinary Education, EarlyView.
Summary Bone oedema‐like lesion is characterised by hyperintense signal in short tau inversion recovery (STIR) sequences on magnetic resonance imaging (MRI). Bone oedema‐like lesions involving the enthesis of the collateral ligament (CL) of the distal interphalangeal joint (DIPJ) have not been investigated as a cause of lameness.
F. Cavallier, F. Cantatore, M. Marcatili, M. Biggi   +3 more
wiley   +1 more source

Successful repair of a carpal sheath synovial hernia using a polypropylene mesh

Equine Veterinary Education, EarlyView.
Summary A cob‐cross mare presented with a carpal sheath synovial hernia on the distolateral antebrachium following carpal sheath tenoscopy to treat a radial physeal exostosis and deep digital flexor tendon injury. The presumed source of pain was the weakened skin over the hernia as the intrathecal pathology identified at the initial tenoscopy had ...
S. R. L. Neild, J. D. Stack, M. D. Cullen, B. M. Curnow   +3 more
wiley   +1 more source

Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection

Asia Pacific Allergy, 2017
Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon.
Wannada Laisuan, Chamard Wongsa, Nizchapha Dchapaphapeaktak, Malinee Tongdee, Jidapa Chatmapanrangsee, T. Rerkpattanapipat   +5 more
semanticscholar   +1 more source