Results 331 to 340 of about 86,728 (368)

Insights into the methodology of acetyl-CoA carboxylase inhibition

Acetyl-CoA carboxylase catalyzes the first committed and regulated step in fatty acid synthesis in all animals, plants and bacteria. In most Gram-positive and Gram-negative bacteria, the enzyme is composed of three proteins: biotin carboxylase, biotin carboxyl carrier protein and carboxyltransferase. The reaction consists of two half-reactions.
Mirela Tkalčić, Čavužić, Brent A, Larson, Grover L, Waldrop   +2 more
openaire   +2 more sources

Coenzyme repression of acetyl-CoA carboxylase by (+)-biotin

Archives of Biochemistry and Biophysics, 1969
Abstract Cell-free sonicated suspensions of L. plantarum were found to have acetyl-CoA carboxylase activity. The product of the reaction, which required ATP, acetyl-CoA and MnCl2 for maximum activity, was identified as malonyl-CoA. Avidin completely inhibited the reaction; the avidin effect was reversed by (+)-biotin.
openaire   +2 more sources

The participation of acetyl-CoA in pyruvate carboxylase

Biochemical and Biophysical Research Communications, 1966
T G, Cooper, C R, Benedict
openaire   +2 more sources

Insulin stimulates the phosphorylation of acetyl-CoA carboxylase

Biochemical and Biophysical Research Communications, 1981
Summary The activity of acetyl-CoA carboxylase is subject to regulation by both allosteric modulation and changes in covalent enzyme phosphorylation. The present study was carried out to investigate changes in the acetyl-CoA carboxylase phosphorylation state following insulin or glucagon exposure in rat hepatocytes.
openaire   +2 more sources

Purification and crystallization of acetyl CoA carboxylase

Life Sciences, 1967
T, Goto, E, Ringelmann, B, Riedel, S, Numa   +3 more
openaire   +2 more sources

Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise.

American Journal of Physiology, 1996
W. Winder, D. Hardie
semanticscholar   +1 more source

Fibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment

Nature Metabolism, 2021
Simon Schwörer, Natalya N Pavlova, Bryan King   +2 more
exaly  

Acetyl‐CoA Carboxylase Inhibitor GS‐0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis

Clinical Gastroenterology and Hepatology, 2018
E. Lawitz, A. Coste, F. Poordad, N. Alkhouri, N. Loo, B. McColgan, J. Tarrant, Tuan Nguyen, Ling Han, C. Chung, A. Ray, J. Mchutchison, M. Subramanian, R. Myers, M. Middleton, C. Sirlin, R. Loomba, Edna Nyangau, M. Fitch, Kelvin W. Li, M. Hellerstein   +20 more
semanticscholar   +1 more source

REGULATION OF ACETYL-CoA CARBOXYLASE

Nutrition Reviews, 2009
openaire   +2 more sources

Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2

Science, 2001
L. Abu-Elheiga, M. Matzuk, K. Abo-Hashema, S. Wakil   +3 more
semanticscholar   +1 more source