Results 331 to 340 of about 400,932 (385)

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, EarlyView.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

H3K14: A histone site closely related to diseases. [PDF]

J Cancer
Fan C, Zeng F, Lei Y, He Q, Liu K, Xu J, Zhou Y.   +6 more
europepmc   +1 more source

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, EarlyView.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Aging aggravated liver ischemia and reperfusion injury by promoting oxidized mtDNA mediated-macrophage pyroptosis through acetylated MCU-dependent calcium uptake. [PDF]

Cell Death Discov
Wu XY, Wang R, Zhang Q, Liu T, Liu JY, Xu XS, Gong JH.   +6 more
europepmc   +1 more source

The Mechanism and Potential Therapeutic Strategies of Vascular Aging

AGING MEDICINE, EarlyView.
The phenotypes of vascular aging vary across different blood vessels. Endothelial dysfunction is observable in the endothelium of all vessels, while vascular structural remodeling primarily occurs in arteries. A decline in organ vascular density mainly affects arterioles, venules, and capillaries, whereas thrombosis predominantly occurs in the ...
Wan‐Zhou Wu, Xuan Wang, Fang‐Fang Wu, Xiao‐Tian Yan, Yong‐Ping Bai   +4 more
wiley   +1 more source

Oxidative stress-induced ZEB1 acetylation drives a hybrid epithelial-mesenchymal phenotype and promotes lung metastasis in triple-negative breast cancer. [PDF]

Redox Biol
Guo M, Wang YJ, Shi J, Cao LX, Ou Y, Jia X, Qi CC, Li ZX, Liu YX, Zuo SY, Shuai QY, Yu TW, Hu HY, Chen X, Feng MD, Xue Y, Wang H, Sun PQ, Liu L, Shi Y, Yang S.   +20 more
europepmc   +1 more source

Visualization of OPN‐Targeted Self‐Assembled Micelles Encapsulated With an SIRT6 Activator and Doped Indocyanine Green for Attenuating Vascular Aging

AGING MEDICINE, EarlyView.
We developed a visualized OPN‐targeted nanodelivery system loaded with MDL800 and ICG to attenuate vascular aging via activating SIRT6 to reduce MMP9 in a mice model, providing a promising anti‐aging strategy for future clinical applications. ABSTRACT Objectives Sirtuin 6 (SIRT6) is a longevity‐associated gene with recognized therapeutic potential for ...
Yan Fang, Wenyue Li, Cheng Qin, Mengqi Xu, Naiyuan Sun, Tingting Lu, Zhiyi Fang, Yan Ma, Linghuan Wang, Sulei Li, Xiaojing Wan, Hui Li, Renzheng Chen, Xiaoying Shen, Lei Tian, Jing Liu, Yi Hou, Feng Cao   +17 more
wiley   +1 more source

Hsp70 and Hsp90 post-translational modifications and translating the chaperone code. [PDF]

Cell Stress Chaperones
Backe SJ, Heritz JA, Mollapour M.
europepmc   +1 more source

Mechanistic insights into post-translational modifications in hepatic fibrosis: pathogenic roles and therapeutic potentials. [PDF]

J Transl Med
Bai X, Liu Z, Li X, Sun R, Yu Z.
europepmc   +1 more source

Will Stub1 Be the Next Target for Pulmonary Hypertension Therapy Development? [PDF]

Am J Respir Cell Mol Biol
Shen Y.
europepmc   +1 more source