Results 41 to 50 of about 60,876 (204)

Síntese de inibidores potenciais de hexosaminidases derivados de N-acetilglicosamina e D-glicose

Orbital: The Electronic Journal of Chemistry, 2012
We report herein the synthesis and characterization of N-acetylglucosamine and D-glucose derivates modified at C-1 for evaluation of antifungal activity as potential hexosaminidases inhibitors.
Lucas Lopardi Franco, Mário C. Brandão, Ricardo José Alves, José Dias Souza Filho   +3 more
doaj   +1 more source

Large‐Scale and Cost‐Effective Fabrication of Ultra‐Thin, Biodegradable Microelectrode Arrays and Pressure Sensors Using Laser Micromachining

Advanced Materials Technologies, EarlyView.
A mask‐free and cost‐effective UV‐pico‐second laser‐based microfabrication method is proposed to fabricate large‐area biodegradable microelectrode arrays and pressure sensors. These devices demonstrate low impedance, good conformability, excellent biocompatibility, and rapid degradation, providing a new route for next‐generation transient electronics ...
Bhavani Prasad Yalagala, Asfand Tanwear, María Cerezo‐Sánchez, Hossein Parvizi, Morteza Amjadi, Hadi Heidari   +5 more
wiley   +1 more source

Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly

Advanced Science, EarlyView.
Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao, Juntao Hu, Juan Du, Shaokun Guo, Youming Hou, Zhihong Li   +5 more
wiley   +1 more source

N-Acetylglucosamine Functions in Cell Signaling

Scientifica, 2012
The amino sugar N-acetylglucosamine (GlcNAc) is well known for the important structural roles that it plays at the cell surface. It is a key component of bacterial cell wall peptidoglycan, fungal cell wall chitin, and the extracellular matrix of animal ...
James B. Konopka
doaj   +1 more source

B4GALNT4‐Mediated Glycosylation of PDK1 Activates the PI3K‐AKT Signaling Pathway to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
This study identifies B4GALNT4 as a key driver of prostate cancer (PCa). It shows that B4GALNT4 glycosylates PDK1 protein at the N531 site, which stabilizes the PDK1 and constitutively activates the PI3K‐AKT pathway. This mechanism promotes tumor cell proliferation, migration, and invasion. The findings establish the B4GALNT4‐PDK1 glycosylation axis as
Shaoqin Jiang, Mengqiang Li, Qingfu Su, Ruiling Dou, Shaoshan Lin, Jili Zhang, Xiaochen Sun, Haolan Yu, Wei Bao, Min Qu, Yan Wang, Chenghua Yang, Xu Gao   +12 more
wiley   +1 more source

Estudos do Mecanismo de Catálise da Pirofosforilase UDP-N-acetilglucosamina do Moniliophthora perniciosa por Métodos QM/MM

Orbital: The Electronic Journal of Chemistry, 2015
The fungus Moniliophthora perniciosa is the causal agent of the witches’ broom disease of cacao (Theobroma cacao). This fungus has a pyrophosphorylase enzyme to catalyze the formation of UDP-N-acetylglucosamine-1-phosphate, an intermediate  in the ...
André L. B. Teles, Manoelito Coelho dos Santos Júnior, Vanildo Martins Lima Braga, Alex Gutterres Taranto   +3 more
doaj   +3 more sources

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source

Host glycan sugar-specific pathways in Streptococcus pneumoniae: galactose as a key sugar in colonisation and infection [corrected].

PLoS ONE, 2015
The human pathogen Streptococcus pneumoniae is a strictly fermentative organism that relies on glycolytic metabolism to obtain energy. In the human nasopharynx S.
Laura Paixão, Joana Oliveira, André Veríssimo, Susana Vinga, Eva C Lourenço, M Rita Ventura, Morten Kjos, Jan-Willem Veening, Vitor E Fernandes, Peter W Andrew, Hasan Yesilkaya, Ana Rute Neves   +11 more
doaj   +1 more source

WGA-based lectin affinity gel electrophoresis: A novel method for the detection of O-GlcNAc-modified proteins. [PDF]

PLoS ONE, 2017
Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc) occurs selectively on serine and/or threonine residues of cytoplasmic and nuclear proteins, and dynamically regulates their molecular functions.
Yuji Kubota, Ko Fujioka, Mutsuhiro Takekawa   +2 more
doaj   +1 more source

An Enzyme‐Like Catalyzed Nanosheets for Redox Stress Oscillation Therapy Against Bacterial Infections

Advanced Science, EarlyView.
Bacterial biofilms form a physicochemical barrier. Their dense network structure and redox homeostasis confer high resistance to antimicrobial treatments and immune‐mediated killing and clearance. In this study, SnSe nanosheets with enzyme‐like properties and piezoelectric catalysis can oscillate to regulate bacterial redox homeostasis and improve the ...
Min Ge, Zhao Guo, Zhiming Zhang, Lanlu Lu, Zesong Ruan, Tingwang Shi, Yunfeng Chen, Ju Huang, Chaoliang Tan, Han Lin   +9 more
wiley   +1 more source