Results 11 to 20 of about 124,541 (336)

Tertiary amine derivatives of chlorochalcone as acetylcholinesterase (AChE) and buthylcholinesterase (BuChE) inhibitors: the influence of chlorine, alkyl amine side chain and α,β-unsaturated ketone group

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
A new series of tertiary amine derivatives of chlorochalcone (4a∼4l) were designed, synthesized and evaluated for the effect on acetylcholinesterase (AChE) and buthylcholinesterase (BuChE).
Xiao-hui Gao, Chao Zhou, Hao-ran Liu, Lin-bo Liu, Jing-jing Tang, Xin-hua Xia   +5 more
doaj   +2 more sources

Oxime Therapy for Brain AChE Reactivation and Neuroprotection after Organophosphate Poisoning

Pharmaceutics, 2022
One of the main problems in the treatment of poisoning with organophosphorus (OPs) inhibitors of acetylcholinesterase (AChE) is low ability of existing reactivators of AChE that are used as antidotes to cross the blood-brain barrier (BBB).
D. Kuznetsova, G. Gaynanova, E. Vasilieva, R. Pavlov, I. Zueva, V. Babaev, D. Kuznetsov, A. Voloshina, K. Petrov, L. Zakharova, O. Sinyashin   +10 more
semanticscholar   +1 more source

Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.

Journal of Medicinal Chemistry, 2021
Based on a multitarget strategy, a series of novel tacrine-pyrimidone hybrids were identified for the potential treatment of Alzheimer's disease (AD).
Hong Yao, G. Uras, Pengfei Zhang, Shengtao Xu, Ying‐Hao Yin, Jie Liu, S. Qin, Xinuo Li, S. Allen, Renren Bai, Qi Gong, Haiyan Zhang, Zheying Zhu, Jinyi Xu   +13 more
semanticscholar   +1 more source

TDP-43 Regulation of AChE Expression Can Mediate ALS-Like Phenotype in Zebrafish

Cells, 2021
The “distal axonopathy” hypothesis in amyotrophic lateral sclerosis (ALS) proposes that pathological changes occur at the neuromuscular junction (NMJ) early in the disease. While acetylcholinesterase (AChE) plays an important role in the functionality of
María-Letizia Campanari, A. Marian, S. Ciura, E. Kabashi   +3 more
semanticscholar   +1 more source

MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy

Biomolecules, 2020
Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer’s disease (AD) development as its overexpression is directly linked to increased tau phosphorylation.
Anas Shamsi, Saleha Anwar, Taj Mohammad, M. Alajmi, A. Hussain, M. Rehman, G. Hasan, A. Islam, M. Hassan   +8 more
semanticscholar   +1 more source

Anti-Parkinson’s Activity of Tribulus terrestris via Modulation of AChE, α-Synuclein, TNF-α, and IL-1β

ACS Omega, 2020
Tribulus terrestris (T.T.) is a rich source of flavonoids and saponins, which have been reported to have neuroprotective and antioxidant potential. The current study was planned to investigate the anti-Parkinson’s activity of T.
Uzma Saleem, Zunera Chauhdary, Zohaib Raza, Shahid Shah, Mahmood-ur Rahman, Parwasha Zaib, B. Ahmad   +6 more
semanticscholar   +1 more source

Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602

Biomolecules, 2020
The study documented here was aimed to find the molecular interactions of some of the cannabinoid constituents of cannabis with acetylcholinesterase (AChE). Molecular docking and LogP determination were performed to predict the AChE inhibitory effect and
Tiyyaba Furqan, Sidra Batool, R. Habib, Mamoona Shah, H. Kalasz, F. Darvas, K. Kuča, E. Nepovimova, S. Batool, S. Nurulain   +9 more
semanticscholar   +1 more source

Prevalencia de infeccion humana por Trypanosoma cruzi en bancos de sangre en Venezuela Prevalence of human infections by Trypanosoma cruzi in Venezuelan blood banks

Revista do Instituto de Medicina Tropical de São Paulo, 1993
Las primeras investigaciones realizadas a nivel de bancos de sangre, durante la década 50, indican que la seroprevalencia por infecciones a T. cruzi entre hemodadores fue de 12%.
Alberto Aché
doaj   +1 more source

Was treibt den Motor an?

Raumforschung und Raumordnung, 2000
Great expectations are currently being pinned on towns and urban regions with regard to the crucial part ascribed to them in shaping the competitive environment in both European and global terms.
Peter Ache
doaj   +1 more source

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

Scientific Reports, 2017
The human genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2. These proteins have been implicated in a number of cellular processes and linked to a variety of tumors.
Rafael M. Couñago, Charles K. Allerston, Pavel Savitsky, Hatylas Azevedo, Paulo H. Godoi, Carrow I. Wells, Alessandra Mascarello, Fernando H. de Souza Gama, Katlin B. Massirer, William J. Zuercher, Cristiano R. W. Guimarães, Opher Gileadi   +11 more
doaj   +1 more source