Results 11 to 20 of about 113,265 (275)

Discovery of Novel Tacrine-Pyrimidone Hybrids as Potent Dual AChE/GSK-3 Inhibitors for the Treatment of Alzheimer's Disease.

Journal of Medicinal Chemistry, 2021
Based on a multitarget strategy, a series of novel tacrine-pyrimidone hybrids were identified for the potential treatment of Alzheimer's disease (AD).
Hong Yao, G. Uras, Pengfei Zhang, Shengtao Xu, Ying‐Hao Yin, Jie Liu, S. Qin, Xinuo Li, S. Allen, Renren Bai, Qi Gong, Haiyan Zhang, Zheying Zhu, Jinyi Xu   +13 more
semanticscholar   +1 more source

MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer’s Disease Therapy

Biomolecules, 2020
Microtubule affinity-regulating kinase (MARK4) plays a key role in Alzheimer’s disease (AD) development as its overexpression is directly linked to increased tau phosphorylation.
Anas Shamsi, Saleha Anwar, Taj Mohammad, M. Alajmi, A. Hussain, M. Rehman, G. Hasan, A. Islam, M. Hassan   +8 more
semanticscholar   +1 more source

Anti-Parkinson’s Activity of Tribulus terrestris via Modulation of AChE, α-Synuclein, TNF-α, and IL-1β

ACS Omega, 2020
Tribulus terrestris (T.T.) is a rich source of flavonoids and saponins, which have been reported to have neuroprotective and antioxidant potential. The current study was planned to investigate the anti-Parkinson’s activity of T.
U. Saleem, Zunera Chauhdary, Zohaib Raza, Shahid Shah, Mahmood-ur Rahman, Parwasha Zaib, B. Ahmad   +6 more
semanticscholar   +1 more source

Cannabis Constituents and Acetylcholinesterase Interaction: Molecular Docking, In Vitro Studies and Association with CNR1 rs806368 and ACHE rs17228602

Biomolecules, 2020
The study documented here was aimed to find the molecular interactions of some of the cannabinoid constituents of cannabis with acetylcholinesterase (AChE). Molecular docking and LogP determination were performed to predict the AChE inhibitory effect and
Tiyyaba Furqan, Sidra Batool, R. Habib, Mamoona Shah, H. Kalasz, F. Darvas, K. Kuča, E. Nepovimova, S. Batool, S. Nurulain   +9 more
semanticscholar   +1 more source

The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity

Natural Product Research, 2019
The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity.
B. Pejin, Kristina Tešanović, D. Jakovljevic, S. Kaisarevic, F. Sibul, M. Rašeta, M. Karaman   +6 more
semanticscholar   +1 more source

Prevalencia de infeccion humana por Trypanosoma cruzi en bancos de sangre en Venezuela Prevalence of human infections by Trypanosoma cruzi in Venezuelan blood banks

Revista do Instituto de Medicina Tropical de São Paulo, 1993
Las primeras investigaciones realizadas a nivel de bancos de sangre, durante la década 50, indican que la seroprevalencia por infecciones a T. cruzi entre hemodadores fue de 12%.
Alberto Aché
doaj   +1 more source

Biomonitoring of Acetylcholinesterase (AChE) Activity among Smallholder Horticultural Farmers Occupationally Exposed to Mixtures of Pesticides in Tanzania

Journal of Environmental and Public Health, 2019
Biomonitoring of pesticides exposure has currently become a matter of great public concern due to the potential health effects of pesticides. This study assessed levels of acetylcholinesterase (AChE) inhibition and associated health effects in ...
J. Kapeleka, E. Sauli, O. Sadik, P. Ndakidemi   +3 more
semanticscholar   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

El legado filosófico-político de Pierre Clastres

Cahiers d’Études Romanes, 2016
L’ethnologue français Pierre Clastres, accompagné des indiens Aché Guayajkí élabore sur les montagnes du Paraguay une réflexion sur la société sans État.
José Manuel Silvero
doaj   +1 more source

Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of novel quinolinone derivatives bearing dithiocarbamate moiety were designed and synthesised as multifunctional AChE inhibitors for the treatment of AD. Most of these compounds exhibited strong and clearly selective inhibition to eeAChE.
Jie Fu, Fengqi Bao, M. Gu, Jing Liu, Zhipeng Zhang, Jiaoli Ding, Sai-Sai Xie, Jinsong Ding   +7 more
semanticscholar   +1 more source