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Identification and molecular docking study of fish roe-derived peptides as potent BACE 1, AChE, and BChE inhibitors.

Food & Function, 2020
Acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and beta-secretase 1 (BACE 1) play vital roles in the development and progression of Alzheimer's disease (AD). The objective of the present study was to identify fish roe-derived anti-AD peptides
Zhipeng Yu   +7 more
semanticscholar   +1 more source

Acetylcholinesterase Enzyme (AChE) as a Biosensor and Biomarker for Pesticides: A Mini Review

Bulletin of Environmental Science and Sustainable Management (e-ISSN 2716-5353), 2020
Due to the increase in pesticide usage the cost of food production has been drastically reduced worldwide. There are dangers related to the ever-increasing pesticide application especially to the non-target biota and to also to the environment at large ...
A. M. Umar, Abubakar Aisami
semanticscholar   +1 more source

Near-Infrared Fluorescence Probe for Evaluating Acetylcholinesterase (AChE) Activity in PC12 Cells and In Situ Tracing AChE Distribution in Zebrafish.

ACS Sensors, 2019
Acetylcholinesterase (AChE) plays crucial roles in numerous physiological processes such as cell differentiation, cell apoptosis, and nerve tissues development.
Jianlong Ma   +6 more
semanticscholar   +1 more source

Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease.

ACS Chemical Neuroscience, 2017
Through drug discovery strategies of repurposing and redeveloping existing drugs, a series of novel tadalafil derivatives were rationally designed, synthesized, and evaluated to seek dual-target AChE/PDE5 inhibitors as good candidate drugs for Alzheimer ...
Fei Mao   +10 more
semanticscholar   +1 more source

In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer's Disease Treatment.

CNS and Neurological Disorders - Drug Targets, 2016
Alzheimer's disease (AD) is the most frequent cause of dementia, especially in the elderly. AD is the most common progressive neurodegenerative disorder, which involves the loss of structure and function of cholinergic neurons.
B. Ali   +9 more
semanticscholar   +1 more source

Ache Life History: The Ecology and Demography of a Foraging People

, 1995
The Ache, whose life history the authors recounts, are a small indigenous population of hunters and gatherers living in the neotropical rainforest of eastern Paraguay. This is part exemplary ethnography of the Ache and in larger part uses this population
K. Hill, A. Hurtado
semanticscholar   +1 more source

Acetylcholinesterase-Fc Fusion Protein (AChE-Fc): A Novel Potential Organophosphate Bioscavenger with Extended Plasma Half-Life.

Bioconjugate chemistry, 2015
Acetylcholinesterase (AChE) is the physiological target of organophosphate nerve agent compounds. Currently, the development of a formulation for prophylactic administration of cholinesterases as bioscavengers in established risk situations of exposure ...
Tal Noy-Porat   +5 more
semanticscholar   +1 more source

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