Results 171 to 180 of about 45,345 (258)

Serum Advanced Glycation End Products as Drivers of Poor Tendon Outcomes in Diabetes? An Emerging Hypothesis and Narrative Review

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Tendon injuries in diabetes heal poorly, with unclear drivers of extracellular matrix disruption and altered mechanics. This narrative review synthesizes in vitro, animal, and human studies, highlighting serum advanced glycation end products as potential systemic contributors.
Eric J. Gutierrez   +3 more
wiley   +1 more source

Deep Unsupervised Domain Adaptation for Translating Cancer Dependency Maps From Cell Lines to Breast Cancer Tumor Genomics

open access: yesGenetic Epidemiology, Volume 50, Issue 5, July 2026.
ABSTRACT The Cancer dependency maps (DepMap) identify genetic dependencies in cancer cells using large‐scale loss‐of‐function screens, providing a foundation for cancer‐specific treatment strategies. However, discrepancies exist between cancer cell line models (CCLs) and patient‐derived tumor models, particularly in translating findings to clinical ...
Yu Shi, Wei Xu, Pingzhao Hu
wiley   +1 more source

Delay in Diagnosis of Classical Homocystinuria

open access: yesJIMD Reports, Volume 67, Issue 4, July 2026.
ABSTRACT Classical homocystinuria (HCU) is an autosomal recessive disorder of methionine metabolism with a wide spectrum of severity and clinical presentation. Timely diagnosis facilitates prompt initiation of treatment, which reduces complications. Our aim was to identify the nature of the first clinical manifestation and time to subsequent diagnosis ...
Subadra Wanninayake   +5 more
wiley   +1 more source

CRISPR‐Cas9 Genome‐Wide Screening in Paediatric Cancer: Functional Genomics for Target Discovery and the Improvement of Existing Therapies

open access: yesMedicinal Research Reviews, Volume 46, Issue 4, Page 989-1004, July 2026.
ABSTRACT CRISPR‐Cas9 genome‐wide screening has been instrumental towards identifying novel targets for drug discovery in cancer research. However, much of this research has centred specifically on adult cancers, with paediatric cancers being underserviced by current research and screening.
Steven He   +2 more
wiley   +1 more source

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