Results 171 to 180 of about 5,105,997 (296)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Chiral Lewis base/Lewis acid/Brønsted acid cooperative catalysis enabled regio- and enantioselective electrophilic sulfenylation/semipinacol rearrangement of allenols. [PDF]

Chem Sci
Wei ZW, Cai QY, Yang LM, Huo YX, Li ZL, Gong XQ, Chen ZM.   +6 more
europepmc   +1 more source

Formation of metallacarboxylic acids through Hieber base reaction. A density functional theory study [PDF]

, 2019
Shahbaz Ahmad, Elisabeth A. Berry, Conor H. Boyle, Christopher G. Hudson, Oliver W. Ireland, Emily A. Thompson, Michæl Bühl   +6 more
openalex   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Streamlined Radiosynthesis of [¹⁸F]Fluproxadine (AF78): An Unprotected Guanidine Precursor Enables Efficient One-Step, Automation-Ready Labeling for Clinical Use. [PDF]

Pharmaceutics
Chen X, Ohta K, Kimura H, Yagi Y, Sasaki T, Nose N, Akehi M, Yamane T, Werner RA, Higuchi T.   +9 more
europepmc   +1 more source

Generating Multimillion Chemical Space Based on the Ugi Four-Сenter Three-Component Reaction with Oxocarboxylic Acids [PDF]

Evgen V. Govor, Sofia Dymura, Oleksandr Viniichuk, Vasyl Naumchyk, Anton V. Zhemera, Dmytro S. Radchenko, Oleksandr O. Grygorenko   +6 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

TiO₂ nanotube-supported Cu(II)-Schiff base complex as an efficient heterogeneous catalyst for A³ coupling reactions under solvent-free conditions. [PDF]

Sci Rep
Sharabiani FJ, Baniyaghoob S, Amini M, Khandar AA.   +3 more
europepmc   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Sustainable base oils from non-edible fats: performance of esterified, epoxidized, and hydroxylated brown grease. [PDF]

RSC Adv
Ksor YB, Smith AD, Smith RC.
europepmc   +1 more source