Results 171 to 180 of about 4,964,055 (321)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Copper catalyzed carbon-selenium bond formation via the coupling reaction of aryl halides, phenylboronic acid and Se. [PDF]

Sci Rep
Shirvandi Z, Ghorashi N, Rostami A.
europepmc   +1 more source

Fluorogenic derivatization of aryl halides based on the formation of biphenyl by Suzuki coupling reaction with phenylboronic acid [PDF]

, 2009
Naoya Kishikawa, Kimiko Kubo, Sherin F. Hammad, Mokhtar M. Mabrouk, Ahmed Habib, Hamed M. El-Fatatry, Kaname Ohyama, Kenichiro Nakashima, Naotaka Kuroda   +8 more
openalex   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

FEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla, Faiza Abbas, Luigia Rossi, Mauro Magnani, Sara Biagiotti   +4 more
wiley   +1 more source

Rapid and Scalable Synthesis of Oxazoles Directly from Carboxylic Acids. [PDF]

J Org Chem
Chavan LN, Pashikanti G, Goodman MM, Liebeskind LS.   +3 more
europepmc   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

4-Aminoquinoline: a comprehensive review of synthetic strategies. [PDF]

Front Chem
Delgado F, Benítez A, Gotopo L, Romero AH.   +3 more
europepmc   +1 more source

Chemical Reactions Occurred in Oxide Glasses and Their Melts and Evaluation by Acid-Base Concept: NMR Investigation of Multi-Component Silicate Glasses

, 2004
Takashi Maekawa
openalex   +2 more sources

Density Functional Theory and Isodesmic Reaction Based Prediction of Four Stepwise Protonation Constants, as log K_H⁽ⁿ⁾, for Nitrilotriacetic Acid. The Importance of a Kind and Protonated Form of a Reference Molecule Used [PDF]

, 2010
Krishna K. Govender, Ignacy Cukrowski
openalex   +1 more source