Results 31 to 40 of about 1,113,567 (292)
Probing Imidazotetrazine Prodrug Activation Mechanisms [PDF]
yesThe archetypal prodrug of the imidazotetrazine class is the anticancer agent temozolomide (TMZ). The prodrug activation kinetics of TMZ show an unusual pH dependence: it is stable in acid and rapidly hydrolyses in alkali (Denny, B.J., et al ...
Ahmad, Leena+3 more
core +3 more sources
For centuries, chemists have researched acid-base reactions and developing numerous different acid-base concepts. Consequentially, it is difficult to teach about acid-base reactions in a clear and conceptually coherent manner.
Krebs Rita Elisabeth+2 more
doaj +1 more source
Zero-dimensional chemical kinetic simulation of ROS/RNSin pulsed pulsed-discharge exposed water [PDF]
The concentration variations of reactive oxygen/nitrogen species in water, such as H2O2, NO2 −, and NO3 − generated by pulsed-discharge plasma exposure, are calculated using reaction rates of chemical reactions and acid-base equilibrium in water.
GIVEN Martin+6 more
core +2 more sources
A method for producing ferulic acid by ultrasound-assisted, homogeneous, base-catalyzed hydrolysis of γ-oryzanol was developed. Experiments were conducted using various reaction temperatures and ratios of γ-oryzanol to base catalyst in both homogeneous ...
Hoa Thi Truong+9 more
doaj +1 more source
Intramolecular acid-base cooperative catalysis is a powerful strategy to promote the nucleophilic additions in synthetic chemistry, since both substrates and nucleophiles can be activated simultaneously, yielding a lower energy reaction pathway. However,
Jiajun Wang+6 more
doaj
Making tau amyloid models in vitro: a crucial and underestimated challenge
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Phenyloctadecanol and phenyloctadecanoic acid were produced via Lewis acid catalyzed reaction of benzene and oleyl alcohol (60 ºC) or oleic acid at (80 ºC) respectively.
M. H.M. Ahmed
doaj +1 more source
Philippine Tung (Reutealis trisperma) is an indigenous nut that is a relatively new feedstock for producing biodiesel in Indonesia. The nature of NaOH base catalyst and reaction temperature plays an important role in the method of biodiesel production ...
Slamet Supriyadi+3 more
doaj +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere+5 more
wiley +1 more source
Microfabricated Silicon Mixers for Submillisecond Quench-Flow Analysis [PDF]
Elucidation of fast chemical reactions such as protein folding requires resolution on a submillisecond time scale. However, most quench-flow and stop-flow techniques only allow chemical processes to be studied after a few milliseconds have elapsed.
Bökenkamp, Dirk+5 more
core +1 more source