Results 61 to 70 of about 4,964,055 (321)

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Allenylphosphine oxides as simple scaffolds for phosphinoylindoles and phosphinoylisocoumarins

Beilstein Journal of Organic Chemistry, 2014
A range of phosphinoylindoles was prepared in one-pot from functionalized propargyl alcohols and a suitable P(III) precursor via a base-mediated reaction. The reaction proceeds via the intermediacy of allenylphosphine oxides.
G. Gangadhararao, Ramesh Kotikalapudi, M. Nagarjuna Reddy, K. C. Kumara Swamy   +3 more
doaj   +1 more source

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

FEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet, Magali Leroy, Alexandre Maes, Ciarán Condon, Frédérique Braun   +4 more
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

New insights into the Lewis acidity of guanidinium species: Lewis acid interaction provides reactivity

Comptes Rendus. Chimie, 2020
A unique reactivity pattern in which the catalyst and the reactant motifs are joined together in a substrate is investigated using density functional theory calculations.
Ashraf, Muhammad Ageel, Li, Cheng, Norouzi, Fataneh, Zhang, Dangquan   +3 more
doaj   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Magnetic amine-functionalized graphene oxide as a novel and recyclable bifunctional nanocatalyst for solvent-free synthesis of pyrano[3,2-c]pyridine derivatives [PDF]

Nanochemistry Research, 2017
The new magnetic amine-functionalized graphene oxide (Fe3O4-GO-NH2) nanocatalyst was prepared through the reaction of 3-aminopropyltriethoxysilane (APTES) with magnetic graphene oxide (Fe3O4-GO).
Shahnaz Rostamizadeh, Asieh Hemmasi, Negar Zekri   +2 more
doaj   +1 more source

Global existence and asymptotic behavior for a reaction-diffusion system with unbounded coefficients [PDF]

arXiv, 2022
We consider a reaction-diffusion system which may serve as a model for a ferment catalytic reaction in chemistry. The model consists of a system of reaction diffusion equations with unbounded time dependent coefficients and different polynomial reaction terms. An exponential decay of the globally bounded solutions is proved.
arxiv  

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

Microscopic description of acid–base equilibrium [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Acid–base reactions are among the most important chemical processes. Yet we lack a simple way of describing this class of reactions as a function of the atomic coordinates.
E. Grifoni, G. Piccini, M. Parrinello
semanticscholar   +1 more source