Results 71 to 80 of about 5,105,997 (296)

Synthesis, Characterization and Spectroscopic Studies of A Novel 2-[(E)-[(2,4-dichlorophenyl)imino]methyl]phenol Schiff Base and Its Metal Complexes

E-Journal of Chemistry, 2012
A novel Schiff base 2-{(E)-[(2,4-dichlorophenyl)imino]methyl}phenol (LB) was synthesized from the condensation reaction of 2,4-dichloroaniline with salicyladehyde in [1:1] ratio in the presence of glacial acetic acid as catalyst. Complexation reaction of
Eman Turky Shamkhy, Isam Hussain T. Al-Karkhi   +1 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Optimized Method for the Synthesis of Alkyne-Modified 2′-Deoxynucleoside Triphosphates

Molecules
A general approach is presented for synthesizing alkyne-modified nucleoside triphosphates via the Sonogashira cross-coupling reaction of unprotected halogenated 2ʹ-deoxynucleoside, followed by monophosphorylation and the reaction of the corresponding ...
Viktoriya E. Kuznetsova, Valeriy E. Shershov, Georgiy F. Shtylev, Ivan Yu. Shishkin, Veronika I. Butvilovskaya, Andrey A. Stomakhin, Irina V. Grechishnikova, Olga A. Zasedateleva, Alexander V. Chudinov   +8 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

SYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1993
Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3 yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl (or propyl)
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Obtenção de cerâmicas quimicamente ligadas a partir de resíduos industriais

Cerâmica
Resumo Neste trabalho investigaram-se cerâmicas quimicamente ligadas com quatro resíduos industriais: areia de fundição, casca cerâmica, escória de níquel e tijolo refratário MgO-C. O sistema foi composto (% em massa) por 17% de fosfato monopotássico, 12%
A. L. Luza, J. Acordi, D. C. N. Fabris, F. Raupp-Pereira, M. D. M. Innocentini, O. K. Montedo   +5 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Development of Integrated Instrument Components of Chemistry Practicum for Acid-Base & Organic Reaction Topics with Green Chemistry Approach

Orbital: The Electronic Journal of Chemistry
Chemistry is a practical subject, not only studied through textbooks but also through practicums. However, practical activities are rarely carried out in schools.
Agustin Tria Retnani, Dhimas Bagus Kurniawan, Ubed Sonai Fahruddin Arrozi   +2 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source