Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Integrated Phenotypic and Genome-Informed Characterization of Environmental Aspergillus Isolates With Potential for Citric Acid Production. [PDF]
MicrobiologyopenKouman WE +4 more
europepmc +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Process For The Production Of Arachidonic Acid And/or Eicosapentaenoic Acid (Patent CA 2621214 A1)
, 2007 Vectors and transgenic plants containing said nucleic acid ...
Sayanova, O. V., Napier, J. A.
core
Associations of palmar surface lactic acid with hand scaling and in vitro pathogen inactivation: A cross-sectional study. [PDF]
PLoS OneNagano K +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
Bile acid dysmetabolism and microbial dysbiosis coincide with <i>Clostridioides difficile</i> infection in pediatric inflammatory bowel disease. [PDF]
NPJ Gut LiverRowe JC, Winston JA.
europepmc +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Repurposing the Natural Product Maslinic Acid for Combating <i>Clostridioides difficile</i> Infections. [PDF]
Int J MicrobiolStolz BJ +3 more
europepmc +1 more source