Results 201 to 210 of about 8,058,686 (308)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Microbiota-Metabolism Axis: Mechanistic Insights and Translational Targets Across Diabetes and Gastrointestinal Disorders. [PDF]

Int J Endocrinol
Akif A, Sultana N, Mikrani I.
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Bioaccessibility and Microbial Metabolism of (Poly)phenol-Rich Dietary Fiber Fractions from Frozen Mixed Berries in an In Vitro Model. [PDF]

J Agric Food Chem
Núñez-Gómez V, Ordóñez-Díaz JL, Moreno-Rojas JM, Pereira-Caro G, Periago MJ, González-Barrio R.   +5 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Oleuropein and punicic acid induce oxidative stress and cytotoxicity in MCF-7 breast cancer cells, with protection by peroxiredoxin antioxidant proteins. [PDF]

Mol Biol Rep
Diiorio S, Quitmeyer B, Phelan SA.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

<i>In vitro</i> colonic fermentation of ferulic acid and <i>trans</i>-resveratrol: kinetic profiling and metabolic convergence.

Food Funct
Tereucán G, Tosi N, Dobani S, Carrieri C, Del Rio D, Henriquez-Aedo K, Bresciani L, Aranda M, Mena P.   +8 more
europepmc   +1 more source

Establishment of hairy root cultures of Lactuca serriola and enhancement of phenolic metabolites through methyl jasmonate elicitation. [PDF]

PLoS One
Asheri M, Farokhzad A, Naghavi M, Ghasemzadeh R, Azadi P, Zargar M.   +5 more
europepmc   +1 more source