Results 41 to 50 of about 4,269 (205)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Separation of Copper and Arsenic from Polluted Acid by Multi-stage Scorodite Precipitation

Kuangchan zonghe liyong
The production process of sulfuric acid produces a large amount of polluted acid containing high concentration of heavy metal ions such as copper, arsenic, and lead.
Fu YANG
doaj   +1 more source

Precipitation of Germanium from Sulphate Solutions Containing Tin and Indium Using Tannic Acid

Applied Sciences, 2019
The precipitation of tannin complex of germanium from sulfuric solutions obtained after dross leaching was investigated. The tested solutions contained mainly zinc, germanium, indium, and tin.
Michał Drzazga, Andrzej Chmielarz, Grzegorz Benke, Katarzyna Leszczyńska-Sejda, Magdalena Knapik, Patrycja Kowalik, Mateusz Ciszewski   +6 more
doaj   +1 more source

Selective Precipitation of Metal Oxalates from Lithium Ion Battery Leach Solutions

Metals, 2020
The separation of cobalt and nickel from sulfatic leach liquors of spent lithium-ion batteries is described in this paper. In addition to the base metals (e.g., cobalt and nickel), components such as manganese and lithium are also present in such leach ...
Eva Gerold, Stefan Luidold, Helmut Antrekowitsch   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Frecvenţa precipitaţiilor acide în ecosisteme forestiere din România în perioada 1998-2004 [Frequency of acid rains in Romanian forest ecosystems in period 1998-2004] [PDF]

Bucovina Forestieră, 2005
Considering that “acid rain” is a rain with ...
Iacoban C
doaj  

Effect of Aqueous Media on the Recovery of Scandium by Selective Precipitation

Metals, 2018
This research presents a novel precipitation method for scandium (Sc) concentrate refining from bauxite residue leachates and the effect of aqueous media on this triple-stage successive precipitation process.
Bengi Yagmurlu, Carsten Dittrich, Bernd Friedrich   +2 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source