Results 1 to 10 of about 89,857 (309)

Breast cancer-derived DAMPs enhance cell invasion and metastasis, while nucleic acid scavengers mitigate these effects [PDF]

Molecular Therapy: Nucleic Acids, 2021
Breast cancer (BC) is the most common malignancy in women. Particular subtypes with aggressive behavior are major contributors to poor outcomes. Triple-negative breast cancer (TNBC) is difficult to treat, pro-inflammatory, and highly metastatic.
Elias O.U. Eteshola, Karenia Landa, Rachel E. Rempel, Ibtehaj A. Naqvi, E. Shelley Hwang, Smita K. Nair, Bruce A. Sullenger   +6 more
doaj   +4 more sources

Targeting DAMPs with nucleic acid scavengers to treat lupus. [PDF]

Transl Res, 2022
Systemic lupus erythematosus (SLE) is a chronic and often progressive autoimmune disorder marked clinically by a variable constellation of symptoms including fatigue, rash, joint pains, and kidney damage. The lungs, heart, gastrointestinal system, and brain can also be impacted, and individuals with lupus are at higher risk for atherosclerosis ...
Olson LB, Hunter NI, Rempel RE, Sullenger BA.   +3 more
europepmc   +3 more sources

1-Amino-but-3-enes scavenge formaldehyde and glyoxylic acid [PDF]

Communications Chemistry
Reactive carbonyl compounds are common pollutants and endogenous metabolites that are often toxic at high concentrations. Removal/detoxification of carbonyl compounds requires selective small molecule scavengers; however, few molecules suitable for this ...
Natasha F. A. Bulman, Vicki L. Emms, Liam A. Thomas, Lilla Beja, Richard J. Hopkinson   +4 more
doaj   +2 more sources

Nucleic acid scavengers inhibit thrombosis without increasing bleeding. [PDF]

Proc Natl Acad Sci U S A, 2012
Development of effective, yet safe, antithrombotic agents has been challenging because such agents increase the propensity of patients to bleed. Recently, naturally occurring polyphosphates such as extracellular DNA, RNA, and inorganic polyphosphates have been shown to activate blood coagulation.
Jain S, Pitoc GA, Holl EK, Zhang Y, Borst L, Leong KW, Lee J, Sullenger BA.   +7 more
europepmc   +4 more sources

A New Perspective on Hydrogen Chloride Scavenging at High Temperatures for Reducing the Smoke Acidity of PVC Cables in Fires. I: An Overview of the Theory, Test Methods, and the European Union Regulatory Status

Fire, 2022
In the European Union, according to the second basic requirement for construction works of Regulation (EU) n. 305/2011, cables permanently installed in residential and public buildings must be classified in terms of reaction to fire, smoke production ...
Gianluca Sarti
doaj   +1 more source

A New Perspective on Hydrogen Chloride Scavenging at High Temperatures for Reducing the Smoke Acidity of PVC Cables in Fires, IV: The Impact of Acid Scavengers at High Temperatures on Flame Retardance and Smoke Emission

Fire, 2023
In PVC compounds, hydrogen chloride plays a fundamental role in ·H and ·OH radical trapping, lowering the flame energy during combustion. Furthermore, it yields actual Lewis acids promoting the cross-linking of the polyene sequences from PVC degradation ...
Iacopo Bassi, Francesca Delchiaro, Claudia Bandinelli, Laura Mazzocchetti, Elisabetta Salatelli, Gianluca Sarti   +5 more
doaj   +1 more source

A New Perspective on Hydrogen Chloride Scavenging at High Temperatures for Reducing the Smoke Acidity of PVC Cables in Fires. II: Some Examples of Acid Scavengers at High Temperatures in the Condensed Phase

Fire, 2022
In the European Union, according to Regulation (EU) n. 305/2011, cables permanently installed in residential and public buildings need additional classification for acidity.
Gianluca Sarti
doaj   +1 more source

A New Perspective on Hydrogen Chloride Scavenging at High Temperatures for Reducing the Smoke Acidity of PVC Cables in Fires V: Comparison between EN 60754-1 and EN 60754-2

Fire, 2023
Regulation (EU) No 305/2011 lays down harmonized conditions for marketing construction products in the European Union. One of its consequences has been the introduction of the product standard EN 50575 and standard EN 130501-6, concerning power, control,
Iacopo Bassi, Claudia Bandinelli, Francesca Delchiaro, Marco Piana, Gianluca Sarti   +4 more
doaj   +1 more source

A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides

Nature Communications, 2021
Synthetic polypeptides are biomimetic materials that are commonly prepared by ring-opening polymerization of amino acid N-carboxyanhydrides (NCAs), but the methods for NCA synthesis usually require anhydrous and air-free conditions.
Zi-You Tian, Zhengchu Zhang, Shuo Wang, Hua Lu   +3 more
doaj   +1 more source

Lipoperoxidation damage of spermatozoa polyunsaturated fatty acids (PUFA): scavenger mechanisms and possible scavenger therapies [PDF]

Frontiers in Bioscience, 2000
The lipid metabolism in sperm cells is important both as one of the main sources for energy production and for cell structure. The double leaflets of the membrane should be considered not simply as a passive lipid film, but as a very specialized structure.
LENZI, Andrea, GANDINI L., PICARDO M., TRAMER F., SANDRI G., PANFILI E.   +5 more
openaire   +3 more sources