Results 41 to 50 of about 89,857 (309)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Role of Anthocyanins in Plant Tolerance to Drought and Salt Stresses

Plants, 2023
Drought and salinity affect various biochemical and physiological processes in plants, inhibit plant growth, and significantly reduce productivity. The anthocyanin biosynthesis system represents one of the plant stress-tolerance mechanisms, activated by ...
Siarhei A. Dabravolski, Stanislav V. Isayenkov   +1 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Visible-light-driven Ag/Bi3O4Cl nanocomposite photocatalyst with enhanced photocatalytic activity for degradation of tetracycline [PDF]

, 2018
In this study, a novel Ag/Bi3O4Cl photocatalyst has been synthesized by a facile photodeposition process. Its photocatalytic performance was evaluated from the degradation of tetracycline (TC) under visible light irradiation (λ > 420 nm).
Che, Guangbo, Che, Huinan, Dong, Hongjun, Jiang, Enhui, Liu, Chunbo, Liu, Xiaoteng   +5 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

OPTIMIZATION OF PREBIOTICS AND OXYGEN SCAVENGERS FOR MICROCAPSULES OF BIFIDOBACTERIUM BIFIDUM BB01 BY TWO-LEVEL FRACTIONAL FACTORIAL DESIGN

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2020
In this paper, protection effects of four oxygen scavengers including sodium erythorbate, ascorbic acid, sodium ascorbate, cysteine hydrochloride and five prebiotics including stachyose, Fructo-oligosaccharide (FOS), Isomalto-oligosaccharide (IOS), Xylo ...
HE CHEN , CHUNXU YAO , YILIN LI, YAJUAN SONG   +3 more
doaj  

N-substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, antioxidant activity, and molecular docking study

Future Journal of Pharmaceutical Sciences, 2018
Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described.
Khairia M. Youssef, Iten M. Fawzy, Hussein I. El-Subbagh   +2 more
doaj   +1 more source

Sustainable Synthesis of p-Hydroxycinnamic Diacids through Proline-Mediated Knoevenagel Condensation in Ethanol: An Access to Potent Phenolic UV Filters and Radical Scavengers

Antioxidants, 2020
p-Hydroxycinnamic diacids are reaction intermediates of the classical Knoevenagel–Doebner condensation between malonic acid and benzaldehydes. As they are generally obtained in low yields, they remain relatively under-studied and under-exploited. Herein,
Benjamin Rioux, Cédric Peyrot, Matthieu M. Mention, Fanny Brunissen, Florent Allais   +4 more
doaj   +1 more source

Systemic Acrolein Elevations in Mice With Experimental Autoimmune Encephalomyelitis and Patients With Multiple Sclerosis [PDF]

, 2018
Demyelination and axonal injury are the key pathological processes in multiple sclerosis (MS), driven by inflammation and oxidative stress. Acrolein, a byproduct and instigator of oxidative stress, has been demonstrated as a neurotoxin in experimental ...
Acosta, Glen, Hayward, Lee, Mattson, David, Race, Nicholas, Shi, Riyi, Tang, Jonathan, Tian, Ran, Tully, Melissa, Zheng, Lingxing   +8 more
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source