Results 1 to 10 of about 487,324 (300)

Genome-wide identification and oxacillinase OXA distribution characteristics of Acinetobacter spp. based on a global database [PDF]

Frontiers in Microbiology, 2023
ObjectiveTo use genomic analysis to identify Acinetobacter spp. and to explore the distribution characteristics of ß-lactamase oxallicinases (blaOXA) among Acinetobacter species globally.MethodsGenomes of global Acinetobacter spp.
Jia Li, Yang Li, Xiaoli Cao, Jie Zheng, Yan Zhang, Hui Xie, Chuchu Li, Chang Liu, Han Shen   +8 more
doaj   +3 more sources

OXA β-lactamases from <i>Acinetobacter</i> spp. are membrane bound and secreted into outer membrane vesicles. [PDF]

mBio
β-lactamases from Gram-negative bacteria are generally regarded as soluble, periplasmic enzymes. NDMs have been exceptionally characterized as lipoproteins anchored to the outer membrane. A bioinformatics study on all sequenced β-lactamases was performed
Capodimonte L, Meireles FTP, Bahr G, Bonomo RA, Dal Peraro M, López C, Vila AJ.   +6 more
europepmc   +3 more sources

Acinetobacter spp. in neonatal sepsis: an urgent global threat [PDF]

Frontiers in Antibiotics
Neonatal sepsis causes substantial morbidity and mortality, the burden of which is carried by low-income countries (LICs). The emergence of multidrug-resistant pathogens in vulnerable neonatal populations poses an urgent threat to infant survival ...
Kamla Pillay, Kamla Pillay, Anirban Ray-Chaudhuri, Seamus O’Brien, Paul Heath, Mike Sharland   +5 more
doaj   +4 more sources

Acinetobacter spp. Infections in Malaysia: A Review of Antimicrobial Resistance Trends, Mechanisms and Epidemiology [PDF]

Frontiers in Microbiology, 2017
Acinetobacter spp. are important nosocomial pathogens, in particular the Acinetobacter baumannii-calcoaceticus complex, which have become a global public health threat due to increasing resistance to carbapenems and almost all other antimicrobial ...
Farahiyah Mohd. Rani, Nor Iza A. Rahman, Salwani Ismail, Ahmed Ghazi Alattraqchi, David W. Cleary, David W. Cleary, Stuart C. Clarke, Stuart C. Clarke, Stuart C. Clarke, Stuart C. Clarke, Chew Chieng Yeo   +10 more
doaj   +3 more sources

In vitro activity of cefiderocol against European Pseudomonas aeruginosa and Acinetobacter spp., including isolates resistant to meropenem and recent β-lactam/β-lactamase inhibitor combinations [PDF]

Microbiology Spectrum
Carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter spp. represent major threats and have few approved therapeutic options. Non-‍fermenting Gram-negative isolates were collected from hospitalized inpatients from 49 sites in 6 European countries
Anne Santerre Henriksen, Katy Jeannot, Antonio Oliver, John D. Perry, Mathias W. Pletz, Stefania Stefani, Ian Morrissey, Christopher Longshaw   +7 more
doaj   +3 more sources

Antimicrobial and Anti-Biofilm Activity of Polymyxin E Alone and in Combination with Probiotic Strains of Bacillus subtilis KATMIRA1933 and Bacillus amyloliquefaciens B-1895 against Clinical Isolates of Selected Acinetobacter spp.: A Preliminary Study

Pathogens, 2021
Acinetobacter spp., the nosocomial pathogen, forms strong biofilms and is resistant to numerous antibiotics, causing persistent infections. This study investigates the antibacterial and anti-biofilm activity of polymyxin E alone and in combination with ...
Munaf AL-Dulaimi, Ammar Algburi, Alyaa Abdelhameed, Maria S. Mazanko, Dmitry V. Rudoy, Alexey M. Ermakov, Michael L. Chikindas   +6 more
doaj   +2 more sources

Update on Multidrug Resistance Efflux Pumps in Acinetobacter spp. [PDF]

Antimicrob Agents Chemother, 2021
Acinetobacter spp. have become of increased clinical importance as studies have shown the antimicrobial resistant potential of these species. Efflux pumps can lead to reduced susceptibility to a variety of antibiotics and are present in large number ...
Kornelsen V, Kumar A.
europepmc   +2 more sources

Treatment effectiveness of antibiotic therapy in Veterans with multidrug-resistant Acinetobacter spp. bacteremia [PDF]

Antimicrobial Stewardship & Healthcare Epidemiology, 2023
Objective: To describe antimicrobial therapy used for multidrug-resistant (MDR) Acinetobacter spp. bacteremia in Veterans and impacts on mortality. Methods: This was a retrospective cohort study of hospitalized Veterans Affairs patients from 2012 to ...
Amanda Vivo, Margaret A. Fitzpatrick, Katie J. Suda, Geneva M. Wilson, Makoto M. Jones, Martin E. Evans, Charlesnika T. Evans   +6 more
doaj   +2 more sources

Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent [PDF]

mBio, 2019
The number and diversity of β-lactamases are steadily increasing. The emergence of β-lactamases that hydrolyze carbapenems poses a significant threat to our antibiotic armamentarium. The explosion of OXA enzymes that are carbapenem hydrolyzers is a major
Melissa D. Barnes, Vijay Kumar, Christopher R. Bethel, Samir H. Moussa, John P. O’Donnell, Joseph Rutter, Caryn E. Good, Kristine M. Hujer, Andrea M. Hujer, Steve H. Marshall, Barry N. Kreiswirth, Sandra S. Richter, Philip N. Rather, Michael R. Jacobs, Krisztina M. Papp‐Wallace, Focco van den Akker, Robert A. Bonomo   +16 more
openalex   +2 more sources

Clinical Isolates of Acinetobacter spp. Are Highly Serum Resistant Despite Efficient Recognition by the Complement System. [PDF]

Front Immunol, 2022
Gram-negative bacteria from the genus Acinetobacter are responsible for life-threating hospital-related infections such as pneumonia, septicemia, and meningitis, especially in immunocompromised patients.
Magda M, Bettoni S, Laabei M, Fairley D, Russo TA, Riesbeck K, Blom AM.   +6 more
europepmc   +2 more sources