LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang +15 more
wiley +1 more source
Stimulating the Stimulated Cortex-Frontocortical Anodal Electric Stimulation Combined With Closed-Loop Acoustic Stimulation During Sleep Impairs Memory in Subjects With High Cognitive Ability. [PDF]
Hausdorf T +5 more
europepmc +1 more source
Forward Electric Stimulation-Induced Interference in Intracochlear Electrocochleography of Acoustic Stimulation in the Cochlea of Guinea Pigs. [PDF]
Min S, Lu T, Chen M, Mao J, Hu X, Li S.
europepmc +1 more source
Laser ultrasound super‐resolution imaging (LUSSI) leverages laser‐generated ultrasound for functional 3D transcranial imaging of brain tumor vasculature. Combined with optoacoustic tomography, it is demonstrated in a glioblastoma model, revealing structural abnormalities, compressed vessels, hemorrhages, and hypoxic regions.
Daniil Nozdriukhin +4 more
wiley +1 more source
Effects of F1-F2 Frequency Spacing on Spectral Integration in Combined Electric and Acoustic Stimulation. [PDF]
Jaisinghani P, Yoon YS.
europepmc +1 more source
Effectiveness of Place-based Mapping in Electric-Acoustic Stimulation Devices. [PDF]
Dillon MT +4 more
europepmc +1 more source
HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer
This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su +13 more
wiley +1 more source
Novel Strategies to Improve Cochlear Drug Delivery Using Acoustic Stimulation. [PDF]
Stéphane G +6 more
europepmc +1 more source
Effects of the Configuration of Hearing Loss on Consonant Perception between Simulated Bimodal and Electric Acoustic Stimulation Hearing. [PDF]
Yoon YS, Whitaker G, Lee YS.
europepmc +1 more source

