Results 121 to 130 of about 248,318 (303)

Global cardiac risk assessment in the Registry Of Pregnancy And Cardiac disease: results of a registry from the European Society of Cardiology

, 2016
To validate the modified World Health Organization (mWHO) risk classification in advanced and emerging countries, and to identify additional risk factors for cardiac events during pregnancy.
Johnson, Mark, Olga Irtyuga, Hall, Roger, Mark R. Johnson, Roos-Hesselink, Jolien, Hall, R., Roger Hall, van Hagen, I.M., Hall, R, Leśniak-Sobelga, A., Lesniak-Sobelga, Agata, Sorour, K.A., Boersma, Eric, van Hagen, Iris, Subias, P E, Maggioni, A.P., Nasser Taha, Parsonage, W.A., Parsonage, William, Irtyuga, O., Escribano Subias, Pilar, Irtyuga, O, Johnson, M.R., Taha, Nasser, Parsonage, W A, Boersma, E., Eric Boersma, Roos-Hesselink, J.W., Agata Leśniak‐Sobelga, Thorne, SA, Taha, N., Johnson, MR, Taha, N (Nasser), Roos - Hesselink, Jolien, Thorne, Sara, Irtyuga, Olga, Khaled A. Sorour, Iris M. van Hagen, Lesniak-Sobelga, A, Pilar Escribano Subías, Maggioni, AP, Thorne, S.A., Sorour, Khaled, Maggioni, Aldo, Sorour, KA, Jolien W. Roos‐Hesselink, Aldo P. Maggioni, Escribano Subías, P., Sara A. Thorne, William A. Parsonage   +49 more
core   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Cardiac Conduction Disorders Due to Acquired or Genetic Causes in Young Adults: A Review of the Current Literature

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Cardiac conduction disorders can manifest in young adults in isolated forms, associated with myocardial diseases or as part of a multiorgan disorder. Underlying causes of cardiac conduction disorders may be genetically determined or acquired.
Cristina Balla, Luca Canovi, Marco Zuin, Luca Di Lenno, Maria L. Berloni, Beatrice de Carolis, Assunta Di Domenico, Elisabetta Tonet, Francesco Vitali, Michele Malagu, Giuseppe Boriani, Matteo Bertini   +11 more
doaj   +1 more source

Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle

, 2005
Background - Although pharmacological block of the slow, delayed rectifier potassium current (I-Ks) by chromanol 293B, L-735,821, or HMR-1556 produces little effect on action potential duration (APD) in isolated rabbit and dog ventricular myocytes, the ...
Lengyel, Csaba Attila, Varró, András, Takács, János, Bogáts, Gábor, Nagy, Zsolt, Lathrop, David A., Biliczki, Péter, Bitay, Miklós, Jost, Norbert, Virág, László, Papp, Gyula   +10 more
core  

Atividade imuno-inflamatória no reparo tecidual da lesão cardíaca induzida por isoproterenol em ratos: implicações e oportunidades terapêuticas [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011Estudos recentes da literatura têm sugerido que um episódio de infarto miocárdico agudo pode deflagrar
Ramos, Gustavo Campos
core  

Relation between mild renal dysfunction and outcomes after coronary artery bypass grafting

, 2005
Background: Risk stratification algorithms for coronary artery bypass grafting (CABG) do not include a weighting for preoperative mild renal impairment defined as a serum creatinine 130 to 199 micromol/L (1.47 to 2.25 mg/dL), which may impact mortality ...
Bonser, Robert, Freemantle, Nick, Rooney, SJ, Cramb, Robert, Pagano, Domenico, Wilson, I. C., Zakeri, R, Lipkin, Graham, Graham, Timothy, Barnet, V, Bonser, R. S., Graham, T. R., Cramb, R., Barnett, V., Freemantle, N., Keogh, B. E., Pagano, D., Keogh, Bruce, Wilson, IC, Barnett, V, Rooney, S. J., Lipkin, G. W., Zakeri, R.   +22 more
core   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source