Results 161 to 170 of about 245,338 (259)

Cardiac evaluation of paediatric athletes. [PDF]

Eur Heart J
Pieles GE, Cavarretta E, Orchard JJ, Abela M, Arbelo E, Budts W, Castelletti S, Claessen G, Corrado D, Di Salvo G, Finocchiaro G, Fritsch P, Gati S, Gerling S, Gonzalez-Corcia MC, Malhotra A, Maestrini V, Niebauer J, Niederseer D, Papadakis M, Oberhoffer R, Pelliccia A, Riding N, Sanz-de la Garza M, Sarquella-Brugada G, Sharma S, Stuart AG, Tiberi M, Zorzi A, D'Ascenzi F.   +29 more
europepmc   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

4D CT angiography and computational biomechanics dataset for structural integrity assessment of abdominal aortic aneurysms. [PDF]

Data Brief
Jamshidian M, Wittek A, Sekhavat S, Alkhatib F, Ritter JC, Parizel PM, Mufty H, Maleux G, Fourneau I, Gizewski ER, Gassner E, Loizides A, Lutz M, Enzmann FK, Bernard F, Minvielle L, Fondanèche A, Polce J, Wood C, Miller K.   +19 more
europepmc   +1 more source

A Dual‐Modal Wearable PPG Smartwatch with AI‐Enhanced Correction for High‐Accuracy and Continuous AF Burden Assessment

Advanced Science, EarlyView.
ABSTRACT Atrial fibrillation (AF) increases the risk of stroke and heart failure, yet accurate quantification of AF burden in daily life remains difficult. Although smartwatch photoplethysmography (PPG) supports continuous monitoring, complex rhythms and signal noise can impair burden estimation.
Song Zuo, Jinglei Wang, Xin Wang, Han Feng, Yize Zhao, Fadong Li, Shaobin Wei, Le Zhou, Zixu Zhao, Songjie Chen, Xiangyi Kong, Jue Wang, Liu He, Shijun Xia, Xin Li, Junmeng Zhang, Xiaoxia Liu, Xueyuan Guo, Ning Zhou, Songnan Li, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Wenwu Zhu, Changsheng Ma   +27 more
wiley   +1 more source

Genetic counselling implementation in dilated cardiomyopathy. [PDF]

Eur Heart J
Verdonschot JAJ, van Spaendonck-Zwarts KY, Hellebrekers DMEI, Asselbergs FW, Behr ER, Charron P, Dawson D, Garcia-Pavia P, Haugaa KH, Jurcut R, Kuchynka P, Lopes LR, Mazzanti A, Metra M, Monserrat L, Kaski JP, Pantazis A, Prasad SK, Rosano G, Seferovic PM, Sheppard MN, Sinagra G, Tome Esteban MT, Heymans SRB, van Tintelen JP.   +24 more
europepmc   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Efficacy and safety of direct oral anticoagulants in pediatric congenital and acquired heart disease: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Thromb J
Bakry HE, Abdellah MI, Khalaf HA, Assem AA, ElGamal MM, Abdo MI, Elkasaby MH, Hassan AA.   +7 more
europepmc   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Maternal Cardiac Disease and Congenital Heart Disease Risk in Offspring.

JAMA Netw Open
Qu Y, Liu X, Lin S, Bloom MS, Liu Y, Yuan H, Wang X, Huang B, Dalakoti M, Gao X, Wu Y, Zhou X, Zhuang J, Chen J, Li J.   +14 more
europepmc   +1 more source