Results 41 to 50 of about 245,338 (259)
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
International Journal of Infectious Diseases, 2023 Objectives: To analyze the differences in short- and long-term prognosis and the predictors of survival between patients with community-acquired Legionella and Streptococcus pneumoniae pneumonia, diagnosed early by urinary antigen testing (UAT). Methods:
Leyre Serrano +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Concomitant Discovery and Treatment of Acquired and Congenital Cardiac Disease
JACC: Case ReportsCoexisting coronary artery disease (CAD) and congenital heart disease (CHD) are rare in adults and pose complex management challenges requiring multidisciplinary coordination.A 79-year-old male with a history of CAD and stenting was referred for evaluation due to worsening dyspnea.
Shantelle Bartra +7 more
openaire +2 more sources
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Scientific Reports, 2022 Idiopathic inflammatory myopathies (IIM) is a group of heterogeneous autoimmune systemic diseases, which not only involve skeletal muscle but also myocardium.
Lu Huang +6 more
doaj +1 more source
Frontiers in Pediatrics, 2023 BackgroundSystemic lupus erythematosus (SLE), a common autoimmune disease predominantly affecting women, has been linked to various complications during pregnancy.
Jong Ho Cha +5 more
doaj +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Sri Lanka Journal of Medicine, 2019 Background: Epidemiology of cardiac diseases among paediatric population remain largely undocumented in Sri Lanka. The objective of this study was to identify the pattern of heart diseases among patients referred to the Paediatric cardiology clinic at ...
S. Irugal Bandara +6 more
doaj +1 more source
Neonatal lupus erythematosus manifested as a complete heart block: A case report
Clinical Case Reports, 2023 Key Clinical Message Fetal bradycardia and congenital complete heart block could be the presentation of neonatal lupus. A high index of suspicion of this condition helps to identify an asymptomatic mother. Abstract Neonatal lupus erythematosus (NLE) is a
Siddinath Gyawali +4 more
doaj +1 more source