Results 171 to 180 of about 3,819,731 (287)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Disease Progression in Iatrogenic Cerebral Amyloid Angiopathy. [PDF]

Neurology
Fandler-Höfler S, Storti B, Kaushik K, Panteleienko L, Pikija S, Rossini F, Damavandi PT, Canavero I, Negro G, DiFrancesco JC, Enzinger C, Gattringer T, Van Etten ES, Bersano A, Wermer MJH, Banerjee G, Werring DJ.   +16 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Evolving patient journey in the management of active perianal fistulizing Crohn's disease: A temporal perspective. [PDF]

Colorectal Dis
Bak MTJ, Verweij MM, Stassen LPS, Buskens CJ, Pronk AM, van der Bilt JDW, Munster LJ, de Boer NKH, Gecse KB, Pierik RB, Witjes CDM, Fitzpatrick CE, Breukink SO, Pierik MJ, Nissen LHC, Verdaasdonk EGG, Gilissen LPL, Bloemen JG, Mares WGN, de Jong GM, Sikkema M, Zimmerman DDE, Bierens-Peters D, de Jonge V, Smeenk RM, Jharap BJ, de Witte E, Romberg-Camps M, Bodelier AGL, Ayez N, Vos XG, van Herwaarden MA, Bos-Poliste S, Indemans FA, van Boeckel PGA, Voskuil MD, van der Wouden EJ, van Dalsen AD, Willemsen-Maas S, Vandebosch S, van Dessel E, Adang RPR, Konsten JLM, van Aalten SM, Wobbes MH, van der Zanden EP, Veltkamp SC, Pultrum BB, Ter Steege RWF, Tielemans MM, van der Have M, Zuur AT, Ter Borg PCJ, Braat H, Aukema TS, Stuyt RJL, van Rossem CC, Verweij KE, van Oostendorp JY, Han-Geurts I, van Tongeren P, Govaert JA, van der Marel S, Horjus CS, Jansen JM, Jansen SV, Bloemendaal ALA, West RL, Kortekaas RTJ, Peeters KCMJ, van der Meulen-de Jong AE, van Schaik FDM, Richir MC, van Dongen KW, Duijvestein M, Bouwknegt DG, Hoogenboom FJ, Visschedijk MC, de Vries AC, van Ruler O, Dutch Initiative on Crohn and Colitis (ICC) & Dutch Initiative on Crohn and Colitis‐Surgery (ICC‐S).   +80 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Correction: Characterization and comparative analysis of the complete mitochondrial genome sequence of Aucklandia lappa Decne. [PDF]

BMC Plant Biol
Xiang C, Zhu Z, Xie S, Chen C, Huang X, Zhang Y, Tao A.   +6 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

dHis-Cu(II) based EPR distances at W-band: navigating the challenges of excitation.

Phys Chem Chem Phys
Moriglioni NA, Limbach Y, El Mkami H, Hunter RI, Ackermann K, Smith GM, Bode BE, Saxena S.   +7 more
europepmc   +1 more source

It Is All About Energy-the Changing Role of X-ray Photons in Photon-counting Detector Computed Tomography: What the Radiologist Needs to Know About kV and keV. [PDF]

Invest Radiol
Hoeijmakers EJI, Martens B, Wildberger JE, Flohr TG, Jeukens CRLPN.   +4 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source