Results 171 to 180 of about 3,918,136 (283)

Life expectancy among women and men with HIV after achieving sustained virologic suppression in the Bronx, New York: a clinical cohort study. [PDF]

Lancet Reg Health Am
Peters BA, Fazzari M, Felsen UR, Jones HE, Ginsberg MS, Hanna DB, Anastos K.   +6 more
europepmc   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Reassessing ¹⁷⁷Lu-PSMA-617 Acquisition Costs: Implications for U.S. Radiopharmaceutical Therapy Cost-Effectiveness Analyses. [PDF]

J Nucl Med
Flannery K, Cavanaugh PF, Steele K.
europepmc   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Clear Positive MOG Antibodies in Adults With Multiple Sclerosis Features: Diagnostic Challenges. [PDF]

Neurol Neuroimmunol Neuroinflamm
Garcia J, Shor N, Boutiere C, Pique J, Boudot De La Motte M, Guillaume M, Delourme A, Zephir H, Ciron J, Carra-Dalliere C, Buissonnière P, Mélé N, Aboab J, Cohen M, Wang A, Couturier J, Rusu D, Thouvenot E, Laplaud DA, Ruet A, Bourre B, Durand-Dubief F, Benyahya L, Collongues N, Michel L, Deschamps R, Papeix C, Audoin B, Stankoff B, Touitou V, Vignal Clermont C, Sterlin D, Marignier R, Maillart E, NOMADMUS study group.   +34 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

High Spatial Resolution ²³Na-MRI for Ischemic Brain Injury Detection. [PDF]

Transl Stroke Res
Jiang Y, Zhou XA, Imai T, Hawley L, Hike D, Mohammed S, Yu G, Ayata C, Chung DY, Yu X.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

[¹⁸F]-flutemetamol across acquisition timeframes: clinical interpretability combining visual read and Centiloids. [PDF]

Neuroimage Clin
Bollack A, Buckley C, Battle M, Smith R, Stromrud E, Mattsson-Carlgren N, Palmqvist S, Hansson O, Takemoto S, March A, La Joie R, Schwarz AJ, Farrar G.   +12 more
europepmc   +1 more source