Results 51 to 60 of about 3,794,499 (287)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Volume I Acquisition Research Creating Synergy for Informed Change, Wednesday Proceedings [PDF]
, 2019 Proceedings of the 16th Annual Acquisition Research Symposium; Volume INaval Postgraduate School Acquisition Research ...
NPS Acquisition Research Program
core +2 more sources
The Proceedings of the 17th Annual Acquisition Research Symposium [PDF]
, 2020 Although this year’s symposium was not held as a live event, ARP continues the annual tradition of making publicly available papers and presentations from the many researchers in the ARP community who were scheduled to appear.
NPS Acquisition Research Program
core +2 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Volume II Acquisition Research Creating Synergy for Informed Change, Thursday Proceedings [PDF]
, 2019 Proceedings of the 16th Annual Acquisition Research Symposium; Volume IINaval Postgraduate School Acquisition Research ...
NPS Acquisition Research Program
core +2 more sources
Communications PhysicsWhile replica symmetry breaking (RSB) was originally formulated in spin-glass theory, its photonic counterpart has been realized in the last decade.
Yishan Chen +7 more
doaj +1 more source
Human Clustering Based on Graph Embedding and Space Functions of Trajectory Stay Points on Campus
Applied SciencesSpatial big data about human mobility have been employed intensively in understanding human spatial activity patterns, which is a central topic in many applications.
Ke Xie +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source