Results 181 to 190 of about 6,039,376 (329)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

SHI: a framework for spatial harmonic imaging. [PDF]

Sci Rep
Diaz JLB, Korvink JG, Kunka D.
europepmc   +1 more source

Upregulated genes of A. baumannii A118 related to iron acquisition system.

Hannaneh Ghavanloughajar (21781716), Moamen M. Elmassry (9440246), Amanda M. V. Brown (3216060), Abdul N. Hamood (408564)   +3 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Simulated Annealing-Guided Geometric Descent-Optimized Frequency-Domain Compression-Based Acquisition Algorithm. [PDF]

Sensors (Basel)
Zhou F, Wang W, Xiao Y, Zhou C.
europepmc   +1 more source

Home Gardener Preferences, Perceptions, Knowledge and Behaviors Associated with Pest Management Strategies and Information Acquisition

, 2009
Amanda Leigh Matheny
openalex   +1 more source

Mergers and acquisitions in LatinAmerica from a buyer’s perspective

Felix Behler
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Structural Vibration Analysis of UAVs Under Ground Engine Test Conditions. [PDF]

Sensors (Basel)
González-Cabrera SI, Camacho-Zamora N, Rojas-Ramirez SR, Gonzalez-Aguilar AM, Vigueras-Zuniga MO, Tejeda-Del-Cueto ME.   +5 more
europepmc   +1 more source

A Brand Orientated Approach in Acquisitions

, 2014
Karl Pollinger, Mikael Omberg
openalex   +1 more source