Results 91 to 100 of about 1,137,474 (237)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Determining the Value of Contractor Performance Assessment Reporting System (CPARS) Narratives For The Acquisition Process [PDF]
, 2014 Annual Acquisition Research SymposiumNaval Postgraduate School Naval Postgraduate School Acquisition Research ...
Clute, Matthew +3 more
core +3 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A programmable fiber laser with full spatiotemporal reconfigurability [PDF]
APL PhotonicsA structured light laser that enables on-demand generation of arbitrary optical field patterns and operates seamlessly across diverse lasing regimes constitutes a transformative platform, offering unprecedented flexibility in high-dimensional optical ...
Mengzhu Zhang +7 more
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Remote Sensing, 2015 The complexity of the single linear hyperspectral pushbroom imaging based on a high altitude airship (HAA) without a three-axis stabilized platform is much more than that based on the spaceborne and airborne.
Aiwu Zhang +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Budding SV3 - Estimating the Cost of Architectural Growth Early in the Life Cycle [PDF]
, 2014 Annual Acquisition Research SymposiumNaval Postgraduate School Naval Postgraduate School Acquisition Research ...
Dabkowski, Matthew +2 more
core +2 more sources