Results 111 to 120 of about 213,692 (300)
HELIN Acquisitions Committee minutes for 4/15/09
, 2009 Minutes of the Acquisitions Committee of the HELIN Consortium for April ...
HELIN Consortium. Acquisitions Committee
core
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
MOVING BEYOND THE LOCAL MARKETPLACE: DYNAMICS OF MERGERS AND ACQUISITIONS [PDF]
Mergers and acquisitions (M&A), as well as the corporate restructuring intercede a great part of the corporate financial world. The most distinguished, the fifth merger wave, found to be five times larger in real terms compared to its predecessor, has ...
Olivera Kostoska
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
HELIN Acquisitions Affinity Group minutes for 9/30/10
, 2010 Minutes of the Acquisitions Affinity Group of the HELIN Consortium for September ...
HELIN Consortium. Acquisitions Affinity Group
core
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
HELIN Acquisitions Committee minutes for 3/25/99
, 1999 Minutes of the Acquisitions Committee of the HELIN Consortium for March ...
HELIN Consortium. Acquisitions Committee
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
HELIN Acquisitions Committee minutes for 10/02/08
, 2008 Minutes of the Acquisitions Committee of the HELIN Consortium for October ...
HELIN Consortium. Acquisitions Committee
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source