Results 61 to 70 of about 213,692 (300)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of the bidding process in the corporate governance of bidding firms: the case of abandoned acquisitions [PDF]
, 2013 This thesis is structured around an empirical investigation of the experience of bidding firms in abandoned acquisitions. Existing research suggests that, in certain circumstances, abandoned acquisitions may play a governance role, disciplining bidder ...
McCann, M
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Is rated debt arm's length? : evidence from mergers and acquisitions [PDF]
, 2011 In this paper we challenge the view that corporate bonds are always arm’s length debt. We analyze the effect of bond ratings on the stock price return to acquirers in M&A transactions, which tend to have significant effects on creditor wealth.
Gropp, Reint E. +3 more
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Economics LettersPrior research suggests that investors value green firms at a premium. We add to this line of research and show that the acquirer’s cumulative abnormal return after the announcement of an acquisition is increasing in the ”greenness” of the target. We find tentative evidence suggesting that this pattern is more pronounced after the 2015 Paris agreement,
Andrea Schertler, Erik Theissen
openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
, 2019 Abstract There are many types of mergers and acquisitions (M&A), be they a minority acquisition to explore a potential high growth emerging market, a takeover of a financially distressed firm with the aim of turning it around, or a private equity firm seeking short- to medium-term returns.
Pauliina Junni, Satu Teerikangas
openaire +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
HELIN Acquisitions Committee minutes for 1/01/03
, 2003 Minutes of the Acquisitions Committee of the HELIN Consortium January ...
HELIN Consortium. Acquisitions Committee
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