Results 61 to 70 of about 1,016 (131)

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, Volume 13, Issue 16, 18 March 2026.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Application of Multimodal Ultrasound Combined With BI‐RADS in Classification and Diagnosis of Non‐Mass Breast Lesions

Journal of Clinical Ultrasound, Volume 54, Issue 3, Page 609-617, March/April 2026.
This study demonstrates that integrating microvascular flow imaging, shear wave elastography, and contrast‐enhanced ultrasound with the BI‐RADS classification significantly improves the diagnostic accuracy for non‐mass breast lesions, offering a more reliable tool for differentiating benign from malignant findings.
Zengdi Yang, Yongyan Lyu, Yanting Yang, Cuiping Xu, Keke Zhang, Xuxu Yang, Feng Chen, Lanlan Cheng, Minglei Ren   +8 more
wiley   +1 more source

Diagnostic performance of the ACR TI-RADS classification in identifying and excluding thyroid malignancy: a multi-correlative retrospective study in a South African tertiary hospital

The Egyptian Journal of Radiology and Nuclear Medicine
Background Thyroid nodule evaluation is essential to exclude malignancy. The American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) stratifies malignancy risk based on sonographic features, guiding biopsy decisions and ...
Neelam Bagratee, Tanusha Sewchuran
doaj   +1 more source

Impact of Diffusion‐Weighted Magnetic Resonance Imaging Parameters on Diagnostic Accuracy for Thyroid Nodules: A Systematic Review and Meta‐Analysis

Journal of Magnetic Resonance Imaging, Volume 63, Issue 3, Page 733-747, March 2026.
ABSTRACT Background Surgery is the gold standard to differentiate benign from malignant thyroid nodules, but it is invasive and often unnecessary in indeterminate cases. Diffusion‐Weighted MRI (DW‐MRI) has emerged as a promising, non‐invasive tool, though its accuracy and the impact of acquisition parameters remain unclear.
Caterina Giannitto, Angela Ammirabile, Giorgia Carnicelli, Ludovica Lofino, Andrea Costantino, Fabrizio Natali, Andrea Alessandro Esposito, Armando De Virgilio, Antonio Lo Casto, Giovanni Savini, Lorenzo Ugga, Giuseppe Mercante, Letterio Salvatore Politi, Steve Connor   +13 more
wiley   +1 more source

Diagnostic Accuracy of O‐RADS US, IOTA Simple Rules, Subjective Assessment, and the Sequential IOTA Simple Rules–Subjective Assessment (SR–SA) Strategy in Adnexal Masses: High Sensitivity Versus the Challenge of Specificity in a Middle‐Resource Setting

Sonography, Volume 13, Issue 1, March 2026.
ABSTRACT Objectives To compare four ultrasound models: O‐RADS US, IOTA Simple Rules (SR), Subjective Assessment (SA), and the Sequential SR–Subjective Assessment strategy (SR–SA) for classifying adnexal masses and to assess whether additional discrimination is possible within intermediate‐risk O‐RADS 3 lesions in a middle‐resource setting.
Carolina Meloni Stecca, Paula Meneguini Badran, Maira Furtado Greco Mazzer, Rodrigo Menezes Jales   +3 more
wiley   +1 more source

Thyroid Fine Needle Aspiration of Nodules ≥ 4 cm: Cytologic Outcomes and Risk Stratification in a Tertiary Centre

Sonography, Volume 13, Issue 1, March 2026.
ABSTRACT Objectives To assess cytologic outcomes of thyroid nodules ≥ 4 cm undergoing FNA and compare malignancy risk between nodules that underwent an FNA by TIRADS criteria versus size alone. Methods A retrospective review of thyroid FNAs from January 2012 to August 2025 was conducted.
Ilona Lavender, Dee Nandurkar
wiley   +1 more source

The Constraint of Crewed Mars Missions Based on Current Radiation Dose Measurements

Space Weather, Volume 24, Issue 3, March 2026.
Abstract Crewed missions to Mars will be a milestone of future space exploration programs. However, the absence of Earth's magnetic field leaves astronauts directly exposed to unattenuated energetic particles in deep space, primarily galactic cosmic rays (GCRs), resulting in significantly higher radiation levels and enhanced health risks. Understanding
Chao Zhang, Weihao Liu, Jingnan Guo, Mikhail Dobynde, Robert F. Wimmer‐Schweingruber   +4 more
wiley   +1 more source

Evaluation and Management of Thyroid Nodules: A Joint Consensus Statement From the British Thyroid Association (BTA), British Association of Endocrine and Thyroid Surgeons (BAETS) and Collaborating Bodies

Clinical Endocrinology, EarlyView.
Ram Moorthy, Saba P. Balasubramanian, Kate Farnell, Mairead Kelly, Gitta Madani, Mufaddal Moonim, Carla Moran, Julia Priestley, Michael Stechman, Emma Watts, Kristien Boelaert   +10 more
wiley   +1 more source

IL40: A Newly Described Cytokine With Conflicting Measurements and Detection Variability—Are There Different Forms?

Scandinavian Journal of Immunology, Volume 103, Issue 3, March 2026.
IL40 has previously been reported to be elevated in rheumatic disease. Here we did not observe higher IL40 plasma levels in rheumatoid arthritis (RA) patients or ANCA‐associated vasculitis (AAV) patients compared to healthy donors and further found large discrepancies in IL40 measurements by two commercial ELISAs.
Nora Euler, Wenqi Huang, Peter Hemmingsson, Anna Juto, Erik Hellbacher, Lars Klareskog, Vivianne Malmström, Iva Gunnarsson, Eva Baecklund, Caroline Grönwall   +9 more
wiley   +1 more source

Retrospective study from a single center to comparison of diagnostic value of three thyroid imaging reporting and data systems in Bethesda III/IV thyroid nodules

Frontiers in Oncology
ObjectivesTo compare the diagnostic value of ACR Thyroid Imaging Reporting and Data System (TI-RADS), K-TIRADS, and C-TIRADS in Bethesda III/IV thyroid nodules.MethodsThis single-center retrospective study classified 80 Bethesda stage III/IV thyroid ...
Jie Guo, Liang Du, Wenjuan Bi, Yuchen Liu, Cuiming Zhang, Cuiming Zhang   +5 more
doaj   +1 more source