Results 231 to 240 of about 1,772,223 (306)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Dosage and Administration-Related Emotional and Clinical Outcomes of Buprenorphine Treatment for Opioid Use Disorder: A Systematic Review and Meta-Analysis. [PDF]

Healthcare (Basel)
Xiao Y, Ramos MR, Montgomery-Marks P.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Glucocorticoids: an enemy or a friend for the dermatologist? recommendations for proper use and safe discontinuation. [PDF]

Endocrine
Sali E, Paschou IA, Dimopoulou SM, Tagka A, Chasapi V, Nicolaidou E, Stratigos AJ, Peppa M, Paschou SA.   +8 more
europepmc   +1 more source

Updates in COPD Management: From Inflammatory Pathways to Targeted Therapies. [PDF]

Eur J Clin Invest
Raman S, Rahman S, Polverino F, Adrish M.   +3 more
europepmc   +1 more source

A Comparison of Long-Acting Progesterone and Intravaginal Device Priming Protocols for Inducing Ovarian Activity in Dromedary Camels. [PDF]

Reprod Domest Anim
Moussa M, Ahmed S, Elbaz M, Pasha K.
europepmc   +1 more source

Hydrogel-Based Depot Systems in Psychiatric Pharmacotherapy: A Narrative Review Rethinking Long-Acting Drug Delivery. [PDF]

Gels
Predoi ED, Târtea A, Taisescu O, Rotaru-Zăvăleanu AD, Ifrim-Predoi AM, Vlad RC, Cătălin B, Mușat MI, Amzoiu MO, Greșiță A.   +9 more
europepmc   +1 more source