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Actinic Keratosis

2014
In some respects actinic keratosis is the most common and best-known pathology in dermatology. Being such an ordinary pathology, actinic keratosis gives nevertheless insight into an extraordinary number of important biological and clinical processes. Actinic keratoses are found in significant numbers on the sun-exposed skin of Caucasians, especially ...
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Pharmacotherapy of actinic keratosis: an update

Expert Opinion on Pharmacotherapy, 2012
Actinic keratosis (AK) represents the initial intraepidermal manifestation of abnormal keratinocyte proliferation, with the potential of progression to squamous cell carcinoma (SCC). Few visible AKs lead to the use of lesion-directed treatments, including ablative and/or surgical procedures.
Sadegh Amini, Brian Berman
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Management of actinic keratosis

Drug and Therapeutics Bulletin, 2013
Actinic keratoses are common, often multiple, epidermal lesions found mainly on the sun-exposed skin of fair-skinned middle-aged and older people.1Over time, lesions may remain unchanged or may proliferate, regress, reappear or develop into squamous cell carcinoma (SCC).2Detectable (spot) lesions are often associated with alteration of the surrounding ...
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The reliability of counting actinic keratosis

Archives of Dermatological Research, 2013
Many epidemiological studies and clinical trials have been performed concerning actinic keratoses. The most eligible endpoint in the majority of articles is counting of actinic keratoses before and after treatments, nevertheless some authors support that this is not a reliable form of evaluation.
Ianhez, M.   +3 more
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Innovations in Actinic Keratosis

Dermatologic Clinics
This review discusses recent progress in actinic keratosis (AK) management, highlighting therapeutic breakthroughs, pathophysiological discoveries, and program implementation strategies. This article also explores advances in photodynamic therapy, introduces new topical treatments, and details the genomic and transcriptomic pathways from AK to squamous
Rawlings E. Lyle   +2 more
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Spreading pigmented actinic keratosis

Journal of the American Academy of Dermatology, 1983
We present four cases of spreading pigmented actinic keratoses, an only recently described pigmented lesion of sun-exposed areas, in which the histologic appearance is that of actinic keratosis with the additional feature of excessive melanin deposition in the lower epidermis and in the upper dermis.
Elizabeth Head   +4 more
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Prevalence of actinic keratosis in Japan

Journal of Dermatological Science, 1997
Most of the epidemiological studies on skin cancer that have been conducted to date have addressed the incidence in light-skinned Caucasians. To determine the prevalence rate of skin cancer and actinic keratosis (AK) on sun-exposed body sites of Japanese in Japan, we examined the skin of 4736 people during health examinations.
Masato Ueda   +7 more
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Actinic Keratosis

Otolaryngologic Clinics of North America, 1993
The actinic keratotic lesion appearing on the sun-exposed skin of the middle-aged and elderly is a common premalignant lesion that infrequently becomes squamous cell carcinoma. Generally, superficially destructive measures provide adequate therapy for this epidermal dysplastic growth. Because of the rare threat of squamous cell carcinoma, a therapeutic
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Actinic keratosis and capecitabine therapy

Journal of Oncology Pharmacy Practice, 2005
Topical application of 5-fluorouracil (5-FU) is one of the most effective clinical strategies available to treat actinic keratosis (AK). During treatment, an apparent toxic skin reaction occurs before dermal quiescence ensues. We report a case of a typical flare of AK in a woman treated with capecitabine for advanced breast cancer.
Rodney F Kovach   +2 more
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Actinic keratosis: Facts and controversies

Clinics in Dermatology, 2010
Actinic keratoses are common lesions that are generally clinically diagnosed. Although currently most actinic keratoses are treated, whether this is truly necessary is debated. Treatment of all actinic keratoses is advocated because preliminary evidence indicates that actinic keratoses may progress to squamous cell carcinomas.
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