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Emerging drugs for actinic keratosis
Expert Opinion on Emerging Drugs, 2010Actinic keratoses (AK) represent a worldwide problem with continuously increasing incidence. AK are characterized by a proliferation of atypical keratinocytes limited to the epidermis, but they may develop into invasive squamous cell carcinoma. In this regard, novel treatment modalities have been developed that allow treatment of the whole actinically ...
Martina Ulrich +2 more
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Management of actinic keratosis
Drug and Therapeutics Bulletin, 2013Actinic keratoses are common, often multiple, epidermal lesions found mainly on the sun-exposed skin of fair-skinned middle-aged and older people.1 Over time, lesions may remain unchanged or may proliferate, regress, reappear or develop into squamous cell carcinoma (SCC).2 Detectable (spot) lesions are often associated with alteration of the ...
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The reliability of counting actinic keratosis
Archives of Dermatological Research, 2013Many epidemiological studies and clinical trials have been performed concerning actinic keratoses. The most eligible endpoint in the majority of articles is counting of actinic keratoses before and after treatments, nevertheless some authors support that this is not a reliable form of evaluation.
Ianhez, M. +3 more
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Innovations in Actinic Keratosis
Dermatologic ClinicsThis review discusses recent progress in actinic keratosis (AK) management, highlighting therapeutic breakthroughs, pathophysiological discoveries, and program implementation strategies. This article also explores advances in photodynamic therapy, introduces new topical treatments, and details the genomic and transcriptomic pathways from AK to squamous
Rawlings E. Lyle +2 more
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Spreading pigmented actinic keratosis
Journal of the American Academy of Dermatology, 1983We present four cases of spreading pigmented actinic keratoses, an only recently described pigmented lesion of sun-exposed areas, in which the histologic appearance is that of actinic keratosis with the additional feature of excessive melanin deposition in the lower epidermis and in the upper dermis.
Elizabeth Head +4 more
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Prevalence of actinic keratosis in Japan
Journal of Dermatological Science, 1997Most of the epidemiological studies on skin cancer that have been conducted to date have addressed the incidence in light-skinned Caucasians. To determine the prevalence rate of skin cancer and actinic keratosis (AK) on sun-exposed body sites of Japanese in Japan, we examined the skin of 4736 people during health examinations.
Masato Ueda +7 more
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Otolaryngologic Clinics of North America, 1993
The actinic keratotic lesion appearing on the sun-exposed skin of the middle-aged and elderly is a common premalignant lesion that infrequently becomes squamous cell carcinoma. Generally, superficially destructive measures provide adequate therapy for this epidermal dysplastic growth. Because of the rare threat of squamous cell carcinoma, a therapeutic
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The actinic keratotic lesion appearing on the sun-exposed skin of the middle-aged and elderly is a common premalignant lesion that infrequently becomes squamous cell carcinoma. Generally, superficially destructive measures provide adequate therapy for this epidermal dysplastic growth. Because of the rare threat of squamous cell carcinoma, a therapeutic
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Sunlight (actinic) keratosis: an update
Journal of preventive medicine and hygiene, 2009Journal of Preventive Medicine and Hygiene, Vol 50, No 4 (2009)
Johan Lemmer +5 more
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Actinic keratosis: Facts and controversies
Clinics in Dermatology, 2010Actinic keratoses are common lesions that are generally clinically diagnosed. Although currently most actinic keratoses are treated, whether this is truly necessary is debated. Treatment of all actinic keratoses is advocated because preliminary evidence indicates that actinic keratoses may progress to squamous cell carcinomas.
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Actinic keratosis and capecitabine therapy
Journal of Oncology Pharmacy Practice, 2005Topical application of 5-fluorouracil (5-FU) is one of the most effective clinical strategies available to treat actinic keratosis (AK). During treatment, an apparent toxic skin reaction occurs before dermal quiescence ensues. We report a case of a typical flare of AK in a woman treated with capecitabine for advanced breast cancer.
Rodney F Kovach +2 more
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