Results 211 to 220 of about 13,692,662 (328)
Computational and neural mechanisms underlying the influence of action affordances on value learning. [PDF]
Nat CommunYi S, O'Doherty JP.
europepmc +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Correction: Simulation insights on the compound action potential in multifascicular nerves. [PDF]
PLoS Comput BiolPLOS Computational Biology Staff.
europepmc +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Investigating action topography in visual cortex and deep artificial neural networks. [PDF]
Nat CommunCortinovis D +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Mirror Neurons and Pain: A Scoping Review of Experimental, Social, and Clinical Evidence. [PDF]
Healthcare (Basel)Cascella M +6 more
europepmc +1 more source