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Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
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Epigenetic switch controls social actions
Neuron, 2022Mutations in epigenetic factors are associated with autism spectrum disorder (ASD). In this issue of Neuron, Yan et al. (2022) show that the antagonism of ASH1L and PRC2 switches the equilibrium of histone methylation at the ephrin receptor A7 locus, causing decreased EphA7 expression, deficits in synaptic pruning, and ASD-like behaviors.
Pedini, Giorgia, Bagni, Claudia
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1985
Imagine that you have bought a car which you expect to drive faster than 120 miles per hour. After breaking it in you try to reach the car’s top speed and find that it is less than 120 miles per hour. Selling the car would cause financial loss, so you have to keep it. Will you be dissatisfied with the car from now on and think you made a wrong decision
Beckmann, J., Irle, M.
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Imagine that you have bought a car which you expect to drive faster than 120 miles per hour. After breaking it in you try to reach the car’s top speed and find that it is less than 120 miles per hour. Selling the car would cause financial loss, so you have to keep it. Will you be dissatisfied with the car from now on and think you made a wrong decision
Beckmann, J., Irle, M.
openaire +2 more sources
Effect anticipation and action control.
Journal of Experimental Psychology: Human Perception and Performance, 2001According to the authors' 2-phase model of action control, people first incidentally acquire bidirectional associations between motor patterns and movement-contingent events and then intentionally use these associations for goal-directed action. The authors tested the model in 4 experiments, each comprising an acquisition phase, in which participants ...
Birgit Elsner, Bernhard Hommel
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Access control by action control
Proceedings of the 13th ACM symposium on Access control models and technologies, 2008We address the problem of defining access control policies that may be used in the evaluation of requests made by client actors, in the course of e-trading, to perform actions on the resources maintained by an e-collective. An e-collective is a group of agents that may act individually or in conjunction with other agents to satisfy a client's request ...
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Action-Control Beliefs and Agentic Actions
2017Throughout their lifespan, agentic individuals consistently update their understandings of situational and environmental contexts and frequently deconstruct and reconstruct their actions as well as the consequences of their actions that arose within these contexts. Highly agentic persons display high aspirations, are motivated to engage the environment,
Rong Chang, Nicole Adams, Todd D. Little
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Parietal control of hand action
Current Opinion in Neurobiology, 1994Recent advances suggest that neurons of the anterior intraparietal area play a critical role in the visual guidance of hand action. The parietal cortex appears to process in-coming binocular visual signals of the three-dimensional features of objects and matches these signals with the motor signals, which come from the ventral premotor cortex, that ...
H, Sakata, M, Taira
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2013
If we think of the ASP.NET Web API framework as a human body, the controller and actions part is the heart of that body. Many components of the Web API framework are glued together by the ApiController class, which is the default controller implementation provided out of the box.
Tugberk Ugurlu +2 more
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If we think of the ASP.NET Web API framework as a human body, the controller and actions part is the heart of that body. Many components of the Web API framework are glued together by the ApiController class, which is the default controller implementation provided out of the box.
Tugberk Ugurlu +2 more
openaire +1 more source
Transcallosal Control of Bilateral Actions
Exercise and Sport Sciences Reviews, 2019The corpus callosum is an important neural structure for controlling and coordinating bilateral movements of the upper limbs; however, there remains a substantial lack of knowledge regarding its association with lower limb control. We argue that transcallosal structure is an integral neural mechanism underlying control of the lower limbs and callosal ...
Sutton B, Richmond, Brett W, Fling
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