Results 71 to 80 of about 5,155,222 (297)
Selecting and Executing Actions for Rewards [PDF]
The Journal of Neuroscience, 2020 Rewards shape human actions. The mere possibility of earning a reward induces substantial improvements in the way we choose and execute actions ([Chen et al., 2017][1]). This observation has raised hope for rehabilitation: reward is regarded as a promising means to magnify the positive effects ...
Pierre Vassiliadis, Gerard Derosiere
openaire +4 more sources
, 2018 Analogous to the mirror neuron system repeatedly described in monkeys as a possible substrate for imitation learning and/or action understanding, a neuronal execution/observation matching system (OEMS) is assumed in humans, but little is known to what ...
Ball, Tonio +3 more
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Detecting execution failures using learned action models [PDF]
, 2007 Planners reason with abstracted models of the behaviours they use to construct plans. When plans are turned into the instructions that drive an executive, the real behaviours interacting with the unpredictable uncertainties of the environment can lead to
Fox, Maria, Gough, Jonathan, Long, Derek
core +1 more source
Automating Fault Tolerance in High-Performance Computational Biological Jobs Using Multi-Agent Approaches [PDF]
, 2014 Background: Large-scale biological jobs on high-performance computing systems require manual intervention if one or more computing cores on which they execute fail.
Alexandrov, Vassil +2 more
core +3 more sources
Motor Action Execution in Reaction-Time Movements
American Journal of Physical Medicine & Rehabilitation, 2019 Objective Reaction-time movements are internally planned in the brain. Presumably, proactive control in reaction-time movements appears as an inhibitory phase preceding movement execution.
I. Tarkka, Pekka Hautasaari
semanticscholar +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Motor resonance facilitates movement execution: an ERP and kinematic study
Frontiers in Human Neuroscience, 2013 Action observation, simulation and execution share neural mechanisms that allow for a common motor representation. It is known that when these overlapping mechanisms are simultaneously activated by action observation and execution, motor performance is ...
Mathilde eMénoret +6 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
A Visual Stack Based Paradigm for Visualization Environments [PDF]
, 2005 We present a new visual paradigm for Visualization Systems, inspired by stack-based programming. Most current implementations of Visualization systems are based on directional graphs.
Gilbert, Matt, Lombeyda, Santiago
core