Results 81 to 90 of about 5,155,222 (297)

Is Action Execution Part of the Decision-Making Process? An Investigation of the Embodied Choice Hypothesis

Journal of Experimental Psychology. Learning, Memory and Cognition, 2017
In this study, we aimed to explore whether action execution is an inherent part of the decision-making process. According to the hypothesis of embodied choice, the decision-making process is bidirectional as action dynamics exert their backward influence
B. Aczél, A. Szollosi, B. Pálfi, Barnabas Szaszi, Pascal J. Kieslich   +4 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Kopernik : modeling business processes for digital customers [PDF]

, 2016
This paper presents the Kopernik methodology for modeling business processes for digital customers. These processes require a high degree of flexibility in the execution of their tasks or actions. We achieve this by using the artifact-centric approach to
Castro, Manuel, Díaz-Montenegro, Sylvia, Estañol Lamarca, Montserrat, Teniente López, Ernest   +3 more
core   +1 more source

Automated Reasoning over Deontic Action Logics with Finite Vocabularies

, 2014
In this paper we investigate further the tableaux system for a deontic action logic we presented in previous work. This tableaux system uses atoms (of a given boolean algebra of action terms) as labels of formulae, this allows us to embrace parallel ...
Castro, Pablo F., Maibaum, Thomas S. E.
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Electrophysiological indexes of the cognitive-motor trade-off associated with motor response complexity in a cognitive task

NeuroImage
Complex actions require more cognitive and motor control than simple ones. Literature shows that to face complexity, the brain must make a compromise between available resources usually giving priority to motor control.
Bianca Maria di Bello, Andrea Casella, Merve Aydin, Stefania Lucia, Francesco Di Russo, Sabrina Pitzalis   +5 more
doaj   +1 more source

HTN Replanning from the Middle

Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2022
When an actor executes a plan, action failures and exogenous events may lead to unexpected states that require replanning from the middle of plan execution.
Yash Bansod, Sunandita Patra, Dana Nau, Mark Roberts   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Infants' mu suppression during the observation of real and mimicked goal-directed actions [PDF]

, 2012
Since their discovery in the early 1990s, mirror neurons have been proposed to be related to many social-communicative abilities, such as imitation. However, research into the early manifestations of the putative neural mirroring system and its role in ...
Handl, A, Pattyn, Griet, Roeyers, Herbert, Ruysschaert, Lieselot, Warreyn, Petra, Wiersema, Roeljan   +5 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source