Results 51 to 60 of about 3,163,690 (243)

Dissociation of Action and Object Naming: Evidence From Cortical Stimulation Mapping [PDF]

, 2005
This cortical stimulation mapping study investigates the neural representation of action and object naming. Data from 13 neurosurgical subjects undergoing awake cortical mapping is presented.
Brinkley, James F, Gibson, Erin K., Poliakov, Andrew V, Ojemann, George A, Corina, David P, Martin, Richard F   +5 more
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Presence of freezing and naming abilities in Parkinson’s disease [PDF]

Neuropsychological Trends, 2010
We found that mildly cognitive impaired patients with PD and freezing are less impaired than comparable patients with PD and no freezing in action naming rather than in object naming.
Giovanni Albani, Riccardo Pignatti, Alessandro Mauro, Carlo Semenza   +3 more
doaj  

Does TMS Disruption of the Left Primary Motor Cortex Affect Verb Retrieval Following Exposure to Pantomimed Gestures?

Frontiers in Neuroscience, 2018
Previous research suggests that meaning-laden gestures, even when produced in the absence of language (i.e., pantomimed gestures), influence lexical retrieval. Yet, little is known about the neural mechanisms that underlie this process. Based on embodied
Ana Murteira, Ana Murteira, Paul F. Sowman, Paul F. Sowman, Lyndsey Nickels   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Object and Action Naming: A Study on Persian-Speaking Children

Iranian Rehabilitation Journal, 2013
Objectives: Nouns and verbs are the central conceptual linguistic units of language acquisition in all human languages. While the noun-bias hypothesis claims that nouns have a privilege in children’s lexical development across languages, studies on
Reza Nilipour, Tahereh Sima Shirazi, Narges Afshordi, Christina Kauschke   +3 more
doaj  

Photographs of manipulable objects are named more quickly than the same objects depicted as line-drawings: Evidence that photographs engage embodiment more than line-drawings

Frontiers in Psychology, 2014
Previous research has shown that photographs of manipulable objects (i.e. those that can be grasped for use with one hand) are named more quickly than non-manipulable objects when they have been matched for object familiarity and age of acquisition.
Joshua P. Salmon, Heath eMatheson, Patricia eMcMullen   +2 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source